Assemblies
Assembly Name:
Cyclin K-CDK12 complex
Multimeric state:
hetero dimer
Accessible surface area:
24110.15 Å2
Buried surface area:
1951.64 Å2
Dissociation area:
975.82
Å2
Dissociation energy (ΔGdiss):
0.27
kcal/mol
Dissociation entropy (TΔSdiss):
12.86
kcal/mol
Symmetry number:
1
PDBe Complex ID:
PDB-CPX-131171
Assembly Name:
Cyclin K-CDK12 complex
Multimeric state:
hetero dimer
Accessible surface area:
23332.82 Å2
Buried surface area:
1394.51 Å2
Dissociation area:
697.25
Å2
Dissociation energy (ΔGdiss):
-0.69
kcal/mol
Dissociation entropy (TΔSdiss):
12.61
kcal/mol
Symmetry number:
1
PDBe Complex ID:
PDB-CPX-131171
Macromolecules
Chains: A, B
Length: 259 amino acids
Theoretical weight: 30.44 KDa
Source organism: Homo sapiens
Expression system: Spodoptera frugiperda
UniProt:
Pfam:
InterPro:
Length: 259 amino acids
Theoretical weight: 30.44 KDa
Source organism: Homo sapiens
Expression system: Spodoptera frugiperda
UniProt:
- Canonical:
O75909 (Residues: 11-267; Coverage: 44%)
Pfam:
InterPro:
- Cyclin-like superfamily
- Cyclin/Cyclin-like subunit Ssn8
- Cyclin, N-terminal
- Cyclin-like domain
- Cyclin, C-terminal domain
Chains: C, D
Length: 326 amino acids
Theoretical weight: 37.82 KDa
Source organism: Homo sapiens
Expression system: Spodoptera frugiperda
UniProt:
Pfam: Protein kinase domain
InterPro:
Length: 326 amino acids
Theoretical weight: 37.82 KDa
Source organism: Homo sapiens
Expression system: Spodoptera frugiperda
UniProt:
- Canonical: Q9NYV4 (Residues: 715-1038; Coverage: 22%)
Pfam: Protein kinase domain
InterPro:
- Protein kinase-like domain superfamily
- Protein kinase domain
- Protein kinase, ATP binding site
- Serine/threonine-protein kinase, active site
