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Crystal structure of human soluble Adenylyl Cyclase with pyrophosphate resulting from soaking with GTP and Magnesium

Source organism: Homo sapiens
Biochemical function: not assigned
Biological process: intracellular signal transduction
Cellular component: not assigned

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EC 4.6.1.1: Adenylate cyclase

Reaction catalysed:
ATP = 3',5'-cyclic AMP + diphosphate
Systematic name:
ATP diphosphate-lyase (cyclizing; 3',5'-cyclic-AMP-forming)
Alternative Name(s):
  • 3',5'-cyclic AMP synthetase
  • ATP diphosphate-lyase (cyclizing)
  • ATP pyrophosphate-lyase
  • Adenyl cyclase
  • Adenylyl cyclase
  • Adenylylcyclase

GO terms

Biochemical function:
  • not assigned
Biological process:
Cellular component:
  • not assigned

Sequence family

Pfam Protein family (Pfam)
PF00211
Domain description: Adenylate and Guanylate cyclase catalytic domain
Occurring in:
  1. Adenylate cyclase type 10
The deposited structure of PDB entry 4ust contains 2 copies of Pfam domain PF00211 (Adenylate and Guanylate cyclase catalytic domain) in Adenylate cyclase type 10. Showing 2 copies in chain A.

InterPro InterPro annotations
IPR001054
Domain description: Adenylyl cyclase class-3/4/guanylyl cyclase
Occurring in:
  1. Adenylate cyclase type 10
IPR029787
Domain description: Nucleotide cyclase
Occurring in:
  1. Adenylate cyclase type 10

Structure domain

CATH CATH domain
3.30.70.1230
Class: Alpha Beta
Architecture: 2-Layer Sandwich
Topology: Alpha-Beta Plaits
Homology: Nucleotide cyclase
Occurring in:
  1. Adenylate cyclase type 10
The deposited structure of PDB entry 4ust contains 2 copies of CATH domain 3.30.70.1230 (Alpha-Beta Plaits) in Adenylate cyclase type 10. Showing 2 copies in chain A.

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