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Crystal structure of human soluble Adenylyl Cyclase with pyrophosphate resulting from soaking with GTP and Magnesium

X-ray diffraction
1.9Å resolution
PDB entry 4ust coloured by chain, front view.
PDB entry 4ust coloured by chain, side view.
PDB entry 4ust coloured by chain, top view.
Source organism: Homo sapiens
Assembly composition:
homo trimer (preferred)
Entry contents: 1 distinct polypeptide molecule

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Assemblies

Assembly 1 (preferred)
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Assembly Name: Adenylate cyclase type 10
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Multimeric state: homo trimer
Accessible surface area: 54010.05 Å2
Buried surface area: 12230.7 Å2
Dissociation area: 3,608.19 Å2
Dissociation energy (ΔGdiss): 32.74 kcal/mol
Dissociation entropy (TΔSdiss): 29.79 kcal/mol
Symmetry number: 3
PDBe Complex ID: PDB-CPX-188671

Macromolecules

Adenylate cyclase type 10
Chain: A
Length: 475 amino acids
Theoretical weight: 54.27 KDa
Source organism: Homo sapiens
Expression system: Trichoplusia ni
UniProt:
  • Canonical: Q96PN6 (Residues: 1-469; Coverage: 29%)
Gene names: ADCY10, SAC
Pfam: Adenylate and Guanylate cyclase catalytic domain
InterPro:
CATH: Nucleotide cyclase
Adenylate cyclase type 10 in PDB entry 4ust, assembly 1, front view.
Adenylate cyclase type 10 in PDB entry 4ust, assembly 1, side view.
Adenylate cyclase type 10 in PDB entry 4ust, assembly 1, top view.
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