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Crystal structure of Aspergillus fumigatus N-myristoyl transferase in complex with myristoyl CoA and a pyrazole sulphonamide ligand

X-ray diffraction
1.8Å resolution
PDB entry 4uwi coloured by chain, front view.
PDB entry 4uwi coloured by chain, side view.
PDB entry 4uwi coloured by chain, top view.
Source organism: Aspergillus fumigatus
Assembly composition:
monomeric (preferred)
Entry contents: 1 distinct polypeptide molecule

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Assemblies

Assembly 1 (preferred)
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Assembly Name: Glycylpeptide N-tetradecanoyltransferase
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Multimeric state: monomeric
Accessible surface area: 17308.29 Å2
Buried surface area: 1546.26 Å2
Dissociation area: 773.13 Å2
Dissociation energy (ΔGdiss): 11.99 kcal/mol
Dissociation entropy (TΔSdiss): 7.18 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-194113
Monomeric assembly 1 of PDB entry 4uwi coloured by chemically distinct molecules, front view.
Monomeric assembly 1 of PDB entry 4uwi coloured by chemically distinct molecules, side view.
Monomeric assembly 1 of PDB entry 4uwi coloured by chemically distinct molecules, top view.
    Assembly 1
Confidence : 95%
No. subunits : 1
Symmetry : None
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3DComplex & QSbio predictionx
No. subunits : 1
Symmetry : None
Evidence : This biological assembly agrees with the prediction of both PISA & EPPIC

Macromolecules

Glycylpeptide N-tetradecanoyltransferase
Chain: A
Length: 407 amino acids
Theoretical weight: 47.04 KDa
Source organism: Aspergillus fumigatus
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: Q9UVX3 (Residues: 86-492; Coverage: 83%)
Gene names: AFUA_4G08070, nmt1
Pfam:
InterPro:
CATH: Aminopeptidase
Glycylpeptide N-tetradecanoyltransferase in PDB entry 4uwi, assembly 1, front view.
Glycylpeptide N-tetradecanoyltransferase in PDB entry 4uwi, assembly 1, side view.
Glycylpeptide N-tetradecanoyltransferase in PDB entry 4uwi, assembly 1, top view.
PDBe-KB: UniProt Coverage View: Q9UVX3  
140750100150200250300350400
 
100200300400
UniProt
Q9UVX3
Chains
Domains
Secondary structure
Flexibility predictions
Early folding residue predictions
Ligand binding sites
Sequence conservation
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