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N-TERMINAL BROMODOMAIN OF HUMAN BRD4 WITH 1,3-dimethyl-2-oxo-2,3- dihydro-1H-1,3-benzodiazole-5-carboxamide

X-ray diffraction
1.37Å resolution
PDB entry 4uyd coloured by chain, front view.
PDB entry 4uyd coloured by chain, side view.
PDB entry 4uyd coloured by chain, top view.
Source organism: Homo sapiens
Assembly composition:
monomeric (preferred)
Entry contents: 1 distinct polypeptide molecule

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Assemblies

Assembly 1 (preferred)
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Assembly Name: Bromodomain-containing protein 4
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Multimeric state: monomeric
Accessible surface area: 7675.58 Å2
Buried surface area: 418.63 Å2
Dissociation area: 107.9 Å2
Dissociation energy (ΔGdiss): -1.35 kcal/mol
Dissociation entropy (TΔSdiss): 0.04 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-130112

Macromolecules

Bromodomain-containing protein 4
Chain: A
Length: 153 amino acids
Theoretical weight: 17.96 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: O60885 (Residues: 44-183; Coverage: 10%)
Gene names: BRD4, HUNK1
Pfam: Bromodomain
InterPro:
CATH: Bromodomain-like
Bromodomain-containing protein 4 in PDB entry 4uyd, assembly 1, front view.
Bromodomain-containing protein 4 in PDB entry 4uyd, assembly 1, side view.
Bromodomain-containing protein 4 in PDB entry 4uyd, assembly 1, top view.
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