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Crystal structure of human ADAMTS-4 in complex with inhibitor (compound 1, 2-(4-chlorophenoxy)-N-{[(4R)-4-methyl-2,5-dioxoimidazolidin-4-yl]methyl} acetamide)

X-ray diffraction
1.24Å resolution
PDB entry 4wk7 coloured by chain, front view.
PDB entry 4wk7 coloured by chain, side view.
PDB entry 4wk7 coloured by chain, top view.
Source organism: Homo sapiens
Assembly composition:
monomeric (preferred)
Entry contents: 1 distinct polypeptide molecule

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Assemblies

Assembly 1 (preferred)
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Assembly Name: A disintegrin and metalloproteinase with thrombospondin motifs 4
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Multimeric state: monomeric
Accessible surface area: 9880.14 Å2
Buried surface area: 265.63 Å2
Dissociation area: 0 Å2
Dissociation energy (ΔGdiss): 0 kcal/mol
Dissociation entropy (TΔSdiss): 0 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-130878

Macromolecules

A disintegrin and metalloproteinase with thrombospondin motifs 4
Chain: A
Length: 235 amino acids
Theoretical weight: 25.48 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
  • Canonical: O75173 (Residues: 213-439; Coverage: 29%)
Gene names: ADAMTS4, KIAA0688, UNQ769/PRO1563
Pfam: Reprolysin (M12B) family zinc metalloprotease
InterPro:
CATH: Collagenase (Catalytic Domain)
A disintegrin and metalloproteinase with thrombospondin motifs 4 in PDB entry 4wk7, assembly 1, front view.
A disintegrin and metalloproteinase with thrombospondin motifs 4 in PDB entry 4wk7, assembly 1, side view.
A disintegrin and metalloproteinase with thrombospondin motifs 4 in PDB entry 4wk7, assembly 1, top view.
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