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Co-crystal Structure of MDM2 in Complex with AM-7209

X-ray diffraction
1.42Å resolution
PDB entry 4wt2 coloured by chain, front view.
PDB entry 4wt2 coloured by chain, side view.
PDB entry 4wt2 coloured by chain, top view.
Source organism: Homo sapiens
Assembly composition:
monomeric (preferred)
Entry contents: 1 distinct polypeptide molecule

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Assemblies

Assembly 1 (preferred)
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Assembly Name: E3 ubiquitin-protein ligase Mdm2
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Multimeric state: monomeric
Accessible surface area: 5951.97 Å2
Buried surface area: 319.34 Å2
Dissociation area: 60.17 Å2
Dissociation energy (ΔGdiss): 8.03 kcal/mol
Dissociation entropy (TΔSdiss): 0.59 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-169499

Macromolecules

E3 ubiquitin-protein ligase Mdm2
Chain: A
Length: 105 amino acids
Theoretical weight: 12.05 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: Q00987 (Residues: 6-110; Coverage: 21%)
Gene name: MDM2
Pfam: SWIB/MDM2 domain
InterPro:
CATH: SWIB/MDM2 domain
E3 ubiquitin-protein ligase Mdm2 in PDB entry 4wt2, assembly 1, front view.
E3 ubiquitin-protein ligase Mdm2 in PDB entry 4wt2, assembly 1, side view.
E3 ubiquitin-protein ligase Mdm2 in PDB entry 4wt2, assembly 1, top view.
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