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Crystal structure of the Type-I signal peptidase from Staphylococcus aureus (SpsB) in complex with an inhibitor peptide (pep3).

X-ray diffraction
1.95Å resolution
PDB entry 4wvj coloured by chain, front view.
PDB entry 4wvj coloured by chain, side view.
PDB entry 4wvj coloured by chain, top view.
Source organisms:
Assembly composition:
hetero dimer (preferred)
Entry contents: 2 distinct polypeptide molecules

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Assemblies

Assembly 1 (preferred)
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Assembly Name: Maltose/maltodextrin-binding periplasmic protein, Signal peptidase IB and peptide
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Multimeric state: hetero dimer
Accessible surface area: 23489.43 Å2
Buried surface area: 2293.06 Å2
Dissociation area: 729.49 Å2
Dissociation energy (ΔGdiss): 6.25 kcal/mol
Dissociation entropy (TΔSdiss): 7.8 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-199638

Macromolecules

Maltose/maltodextrin-binding periplasmic protein; Signal peptidase IB
Chain: A
Length: 533 amino acids
Theoretical weight: 59.19 KDa
Source organisms: Expression system: Escherichia coli K-12
UniProt:
  • Canonical: P0AEX9 (Residues: 33-393; Coverage: 98%)
  • Canonical: Q5HHB9 (Residues: 26-175; Coverage: 79%)
    • nullnull
Gene names: JW3994, SACOL0969, b4034, malE, spsB
Pfam:
InterPro:
Maltose/maltodextrin-binding periplasmic protein in PDB entry 4wvj, assembly 1, front view.
Maltose/maltodextrin-binding periplasmic protein in PDB entry 4wvj, assembly 1, side view.
Maltose/maltodextrin-binding periplasmic protein in PDB entry 4wvj, assembly 1, top view.
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inhibitor peptide (PEP3)
Chain: D
Length: 14 amino acids
Theoretical weight: 1.16 KDa
Source organism: Staphylococcus aureus
Expression system: Not provided
inhibitor peptide (PEP3) in PDB entry 4wvj, assembly 1, front view.
inhibitor peptide (PEP3) in PDB entry 4wvj, assembly 1, side view.
inhibitor peptide (PEP3) in PDB entry 4wvj, assembly 1, top view.
Molecule details ›

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