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Crystal Structure of Scribble PDZ34 tandem in complex with its target peptide

X-ray diffraction
2.5Å resolution
PDB entry 4wyu coloured by chain, front view.
PDB entry 4wyu coloured by chain, side view.
PDB entry 4wyu coloured by chain, top view.
Source organisms:
Assembly composition:
hetero dimer (preferred)
Entry contents: 2 distinct polypeptide molecules

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Assemblies

Assembly 1 (preferred)
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Assembly Name: Protein scribble homolog and peptide
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Multimeric state: hetero dimer
Accessible surface area: 10966.57 Å2
Buried surface area: 1498.48 Å2
Dissociation area: 521.26 Å2
Dissociation energy (ΔGdiss): 1.94 kcal/mol
Dissociation entropy (TΔSdiss): 6.81 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-165335
Assembly 2
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Assembly Name: Protein scribble homolog and peptide
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Multimeric state: hetero dimer
Accessible surface area: 10914.78 Å2
Buried surface area: 1649.63 Å2
Dissociation area: 524.34 Å2
Dissociation energy (ΔGdiss): 3.02 kcal/mol
Dissociation entropy (TΔSdiss): 6.87 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-165335

Macromolecules

Protein scribble homolog
Chains: A, B
Length: 212 amino acids
Theoretical weight: 22.17 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: Q14160 (Residues: 992-1203; Coverage: 13%)
Gene names: CRIB1, KIAA0147, LAP4, SCRB1, SCRIB, VARTUL
Pfam: PDZ domain
InterPro:
CATH: Pdz3 Domain
Protein scribble homolog in PDB entry 4wyu, assembly 1, front view.
Protein scribble homolog in PDB entry 4wyu, assembly 1, side view.
Protein scribble homolog in PDB entry 4wyu, assembly 1, top view.
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peptide SER-TRP-PHE-GLN-THR-ASP-LEU
Chains: C, D
Length: 7 amino acids
Theoretical weight: 896 Da
Source organism: synthetic construct
Expression system: Not provided
peptide SER-TRP-PHE-GLN-THR-ASP-LEU in PDB entry 4wyu, assembly 1, front view.
peptide SER-TRP-PHE-GLN-THR-ASP-LEU in PDB entry 4wyu, assembly 1, side view.
peptide SER-TRP-PHE-GLN-THR-ASP-LEU in PDB entry 4wyu, assembly 1, top view.
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