› › Structure analysis

The crystal structure of mupain-1-16-D9A in complex with murinised human uPA at pH7.4

X-ray diffraction
1.9Å resolution
PDB entry 4x1s coloured by chain, front view.
PDB entry 4x1s coloured by chain, side view.
PDB entry 4x1s coloured by chain, top view.
Source organisms:
Assembly composition:
hetero dimer (preferred)
Entry contents: 2 distinct polypeptide molecules

Quick links

Assemblies

Assembly 1 (preferred)
Download    3D Visualisation
Assembly Name: Urokinase-type plasminogen activator short chain A and peptide
hide full assembly name
Multimeric state: hetero dimer
Accessible surface area: 11404.87 Å2
Buried surface area: 1486.58 Å2
Dissociation area: 743.29 Å2
Dissociation energy (ΔGdiss): 5.33 kcal/mol
Dissociation entropy (TΔSdiss): 7.36 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-133280

Macromolecules

mupain-1-16
Chain: P
Length: 10 amino acids
Theoretical weight: 1.06 KDa
Source organism: synthetic construct
Expression system: Not provided
mupain-1-16 in PDB entry 4x1s, assembly 1, front view.
mupain-1-16 in PDB entry 4x1s, assembly 1, side view.
mupain-1-16 in PDB entry 4x1s, assembly 1, top view.
Molecule details ›

Search similar proteins

Urokinase-type plasminogen activator chain B
Chain: U
Length: 247 amino acids
Theoretical weight: 27.87 KDa
Source organism: Homo sapiens
Expression system: Komagataella pastoris
UniProt:
  • Canonical: P00749 (Residues: 179-425; Coverage: 60%)
Gene name: PLAU
Pfam: Trypsin
InterPro:
CATH: Trypsin-like serine proteases
Urokinase-type plasminogen activator chain B in PDB entry 4x1s, assembly 1, front view.
Urokinase-type plasminogen activator chain B in PDB entry 4x1s, assembly 1, side view.
Urokinase-type plasminogen activator chain B in PDB entry 4x1s, assembly 1, top view.
Molecule details ›

Search similar proteins

Quick links