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Structure of IL-18 SER Mutant V

X-ray diffraction
2.85Å resolution
PDB entry 4xfu coloured by chain, front view.
PDB entry 4xfu coloured by chain, side view.
PDB entry 4xfu coloured by chain, top view.
Source organism: Homo sapiens
Assemblies composition:
monomeric (preferred)
homo dimer
Entry contents: 1 distinct polypeptide molecule

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Assemblies

Assembly 1 (preferred)
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Assembly Name: Interleukin-18
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Multimeric state: monomeric
Accessible surface area: 8254.51 Å2
Buried surface area: 0.0 Å2
Dissociation area: 0 Å2
Dissociation energy (ΔGdiss): 0 kcal/mol
Dissociation entropy (TΔSdiss): 0 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-171913
Assembly 2
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Assembly Name: Interleukin-18
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Multimeric state: monomeric
Accessible surface area: 8373.13 Å2
Buried surface area: 0.0 Å2
Dissociation area: 0 Å2
Dissociation energy (ΔGdiss): 0 kcal/mol
Dissociation entropy (TΔSdiss): 0 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-171913
Assembly 3
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Assembly Name: Interleukin-18
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Multimeric state: homo dimer
Accessible surface area: 15854.81 Å2
Buried surface area: 772.83 Å2
Dissociation area: 386.41 Å2
Dissociation energy (ΔGdiss): -1.94 kcal/mol
Dissociation entropy (TΔSdiss): 11.77 kcal/mol
Symmetry number: 2
PDBe Complex ID: PDB-CPX-171918

Macromolecules

Interleukin-18
Chains: A, B
Length: 157 amino acids
Theoretical weight: 18.15 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: Q14116 (Residues: 37-193; Coverage: 81%)
Gene names: IGIF, IL18, IL1F4
Pfam: Interleukin-1 / 18
InterPro:
CATH: Trefoil (Acidic Fibroblast Growth Factor, subunit A)
Interleukin-18 in PDB entry 4xfu, assembly 1, front view.
Interleukin-18 in PDB entry 4xfu, assembly 1, side view.
Interleukin-18 in PDB entry 4xfu, assembly 1, top view.
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