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Crystal structure of the NanB sialidase from streptococcus pneumoniae in complex with Optactin and 2-[(3-Chlorobenzyl)ammonio]ethanesulfonate

X-ray diffraction
2.1Å resolution
PDB entry 4xhx coloured by chain, front view.
PDB entry 4xhx coloured by chain, side view.
PDB entry 4xhx coloured by chain, top view.
Source organism: Streptococcus pneumoniae TIGR4
Assembly composition:
monomeric (preferred)
Entry contents: 1 distinct polypeptide molecule

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Assemblies

Assembly 1 (preferred)
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Assembly Name: Sialidase B
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Multimeric state: monomeric
Accessible surface area: 24935.55 Å2
Buried surface area: 602.47 Å2
Dissociation area: 125.13 Å2
Dissociation energy (ΔGdiss): -4.37 kcal/mol
Dissociation entropy (TΔSdiss): 0.12 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-176218

Macromolecules

Sialidase B
Chain: A
Length: 658 amino acids
Theoretical weight: 73.52 KDa
Source organism: Streptococcus pneumoniae TIGR4
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: Q54727 (Residues: 39-696; Coverage: 99%)
Gene names: SP_1687, nanB
Pfam:
InterPro:
CATH:
Sialidase B in PDB entry 4xhx, assembly 1, front view.
Sialidase B in PDB entry 4xhx, assembly 1, side view.
Sialidase B in PDB entry 4xhx, assembly 1, top view.
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