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Binary complex of human polymerase nu and DNA with the finger domain closed and thumb domain rotated out

X-ray diffraction
3.2Å resolution
PDB entry 4xvm coloured by chain, front view.
PDB entry 4xvm coloured by chain, side view.
PDB entry 4xvm coloured by chain, top view.
Source organism: Homo sapiens
Assembly composition:
hetero trimer (preferred)
Entry contents: 1 distinct polypeptide molecule
2 distinct DNA molecules

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Assemblies

Assembly 1 (preferred)
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Assembly Name: DNA polymerase nu and DNA
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Multimeric state: hetero trimer
Accessible surface area: 32265.5 Å2
Buried surface area: 3945.86 Å2
Dissociation area: 983.55 Å2
Dissociation energy (ΔGdiss): 1.07 kcal/mol
Dissociation entropy (TΔSdiss): 10.61 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-118294

Macromolecules

DNA polymerase nu
Chain: A
Length: 666 amino acids
Theoretical weight: 74.76 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
  • Canonical: Q7Z5Q5 (Residues: 194-859; Coverage: 74%)
Gene name: POLN
Pfam:
InterPro:
DNA polymerase nu in PDB entry 4xvm, assembly 1, front view.
DNA polymerase nu in PDB entry 4xvm, assembly 1, side view.
DNA polymerase nu in PDB entry 4xvm, assembly 1, top view.
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DNA chain T
Name: DNA (5'-D(*CP*TP*AP*GP*CP*GP*TP*CP*A)-3')
Representative chains: T
Source organism: Homo sapiens [9606]
Expression system: Not provided
Length: 9 nucleotides
Theoretical weight: 2.72 KDa
DNA (5'-D(*CP*TP*AP*GP*CP*GP*TP*CP*A)-3') in PDB entry 4xvm, assembly 1, front view.
DNA (5'-D(*CP*TP*AP*GP*CP*GP*TP*CP*A)-3') in PDB entry 4xvm, assembly 1, side view.
DNA (5'-D(*CP*TP*AP*GP*CP*GP*TP*CP*A)-3') in PDB entry 4xvm, assembly 1, top view.
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DNA chain P
Name: DNA (5'-D(*GP*AP*TP*CP*TP*GP*AP*CP*GP*CP*TP*AP*G)-3')
Representative chains: P
Source organism: Homo sapiens [9606]
Expression system: Not provided
Length: 13 nucleotides
Theoretical weight: 4.01 KDa
DNA (5'-D(*GP*AP*TP*CP*TP*GP*AP*CP*GP*CP*TP*AP*G)-3') in PDB entry 4xvm, assembly 1, front view.
DNA (5'-D(*GP*AP*TP*CP*TP*GP*AP*CP*GP*CP*TP*AP*G)-3') in PDB entry 4xvm, assembly 1, side view.
DNA (5'-D(*GP*AP*TP*CP*TP*GP*AP*CP*GP*CP*TP*AP*G)-3') in PDB entry 4xvm, assembly 1, top view.
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