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HLA-B*1801 in complex with a self-peptide, DELEIKAY

X-ray diffraction
1.426Å resolution
PDB entry 4xxc coloured by chain, front view.
PDB entry 4xxc coloured by chain, side view.
PDB entry 4xxc coloured by chain, top view.
Source organism: Homo sapiens
Assembly composition:
hetero trimer (preferred)
Entry contents: 3 distinct polypeptide molecules

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Assemblies

Assembly 1 (preferred)
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Assembly Name: Major Histocompatibility Complex
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Multimeric state: hetero trimer
Accessible surface area: 18855.53 Å2
Buried surface area: 4515.81 Å2
Dissociation area: 1,284.56 Å2
Dissociation energy (ΔGdiss): 5.48 kcal/mol
Dissociation entropy (TΔSdiss): 12.07 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-135213

Macromolecules

HLA class I histocompatibility antigen, B alpha chain
Chain: A
Length: 279 amino acids
Theoretical weight: 32.05 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P01889 (Residues: 25-303; Coverage: 83%)
Gene names: HLA-B, HLAB
Pfam:
InterPro:
CATH:
HLA class I histocompatibility antigen, B alpha chain in PDB entry 4xxc, assembly 1, front view.
HLA class I histocompatibility antigen, B alpha chain in PDB entry 4xxc, assembly 1, side view.
HLA class I histocompatibility antigen, B alpha chain in PDB entry 4xxc, assembly 1, top view.
PDBe-KB: UniProt Coverage View: P01889  
127920406080100120140160180200220240260
 
100200
UniProt
P01889
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Secondary structure
Flexibility predictions
Early folding residue predictions
Ligand binding sites
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Beta-2-microglobulin
Chain: C
Length: 100 amino acids
Theoretical weight: 11.88 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P61769 (Residues: 21-119; Coverage: 100%)
Gene names: B2M, CDABP0092, HDCMA22P
Pfam: Immunoglobulin C1-set domain
InterPro:
CATH: Immunoglobulins
Beta-2-microglobulin in PDB entry 4xxc, assembly 1, front view.
Beta-2-microglobulin in PDB entry 4xxc, assembly 1, side view.
Beta-2-microglobulin in PDB entry 4xxc, assembly 1, top view.
PDBe-KB: UniProt Coverage View: P61769  
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ASP-GLU-LEU-GLU-ILE-LYS-ALA-TYR
Chain: B
Length: 8 amino acids
Theoretical weight: 981 Da
Source organism: Homo sapiens
Expression system: Not provided
ASP-GLU-LEU-GLU-ILE-LYS-ALA-TYR in PDB entry 4xxc, assembly 1, front view.
ASP-GLU-LEU-GLU-ILE-LYS-ALA-TYR in PDB entry 4xxc, assembly 1, side view.
ASP-GLU-LEU-GLU-ILE-LYS-ALA-TYR in PDB entry 4xxc, assembly 1, top view.
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