Function and Biology

Crystal structure of human AKR1B10 complexed with NADP+ and JF0049

Source organism: Homo sapiens
Biochemical function: all-trans-retinol dehydrogenase (NADP+) activity
Biological process: cellular detoxification of aldehyde
Cellular component: cytosol

EC 1.1.1.54: Allyl-alcohol dehydrogenase

Reaction catalysed:
Allyl alcohol + NADP(+) = acrolein + NADPH
Systematic name:
Allyl-alcohol:NADP(+) oxidoreductase

EC 1.1.1.300: NADP-retinol dehydrogenase

Reaction catalysed:
All-trans-retinol + NADP(+) = all-trans-retinal + NADPH
Systematic name:
Retinol:NADP(+) oxidoreductase
Alternative Name(s):
  • All-trans retinal reductase
  • All-trans-retinol dehydrogenase
  • NADP(H)-dependent retinol dehydrogenase/reductase
  • PSDR1
  • RDH11
  • RDH12
  • RDH13
  • RDH14
  • RalR1
  • Retinol dehydrogenase (NADP(+))
  • Retinol dehydrogenase 12
  • Retinol dehydrogenase 14

Sequence family

Pfam Protein family (Pfam)
PF00248
Domain description: Aldo/keto reductase family
Occurring in:
  1. Aldo-keto reductase family 1 member B10
The deposited structure of PDB entry 4xzl contains 1 copy of Pfam domain PF00248 (Aldo/keto reductase family) in Aldo-keto reductase family 1 member B10. Showing 1 copy in chain A [auth X].

InterPro InterPro annotations
IPR020471
Domain description: Aldo-keto reductase
Occurring in:
  1. Aldo-keto reductase family 1 member B10
IPR018170
Domain description: Aldo/keto reductase, conserved site
Occurring in:
  1. Aldo-keto reductase family 1 member B10
IPR036812
Domain description: NADP-dependent oxidoreductase domain superfamily
Occurring in:
  1. Aldo-keto reductase family 1 member B10
IPR023210
Domain description: NADP-dependent oxidoreductase domain
Occurring in:
  1. Aldo-keto reductase family 1 member B10

Structure domain

CATH CATH domain
3.20.20.100
Class: Alpha Beta
Architecture: Alpha-Beta Barrel
Topology: TIM Barrel
Homology: NADP-dependent oxidoreductase domain
Occurring in:
  1. Aldo-keto reductase family 1 member B10
The deposited structure of PDB entry 4xzl contains 1 copy of CATH domain 3.20.20.100 (TIM Barrel) in Aldo-keto reductase family 1 member B10. Showing 1 copy in chain A [auth X].