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Crystal structure of human AKR1B10 complexed with NADP+ and JF0049

X-ray diffraction
1.7Å resolution
PDB entry 4xzl coloured by chain, front view.
PDB entry 4xzl coloured by chain, side view.
PDB entry 4xzl coloured by chain, top view.
Source organism: Homo sapiens
Assembly composition:
monomeric (preferred)
Entry contents: 1 distinct polypeptide molecule

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Assemblies

Assembly 1 (preferred)
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Assembly Name: Aldo-keto reductase family 1 member B10
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Multimeric state: monomeric
Accessible surface area: 13840.89 Å2
Buried surface area: 1441.15 Å2
Dissociation area: 105.87 Å2
Dissociation energy (ΔGdiss): -3 kcal/mol
Dissociation entropy (TΔSdiss): -0.29 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-129914

Macromolecules

Aldo-keto reductase family 1 member B10
Chain: X
Length: 316 amino acids
Theoretical weight: 36.39 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: O60218 (Residues: 1-316; Coverage: 100%)
Gene names: AKR1B10, AKR1B11
Pfam: Aldo/keto reductase family
InterPro:
CATH: NADP-dependent oxidoreductase domain
Aldo-keto reductase family 1 member B10 in PDB entry 4xzl, assembly 1, front view.
Aldo-keto reductase family 1 member B10 in PDB entry 4xzl, assembly 1, side view.
Aldo-keto reductase family 1 member B10 in PDB entry 4xzl, assembly 1, top view.
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