› › Structure analysis

CCM2 HHD in complex with MEKK3 NPB1

X-ray diffraction
2.35Å resolution
PDB entry 4y5o coloured by chain, front view.
PDB entry 4y5o coloured by chain, side view.
PDB entry 4y5o coloured by chain, top view.
Source organism: Homo sapiens
Assembly composition:
hetero dimer (preferred)
Entry contents: 2 distinct polypeptide molecules

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Assemblies

Assembly 1 (preferred)
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Assembly Name: Mitogen-activated protein kinase kinase kinase 3 and Cerebral cavernous malformations 2 protein
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Multimeric state: hetero dimer
Accessible surface area: 10143.32 Å2
Buried surface area: 2594.94 Å2
Dissociation area: 1,297.47 Å2
Dissociation energy (ΔGdiss): 10.94 kcal/mol
Dissociation entropy (TΔSdiss): 10.78 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-189267

Macromolecules

Cerebral cavernous malformations 2 protein
Chain: A
Length: 98 amino acids
Theoretical weight: 11.16 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: Q9BSQ5 (Residues: 283-379; Coverage: 22%)
Gene names: C7orf22, CCM2, PP10187
Pfam: Cerebral cavernous malformation protein, harmonin-homology
InterPro:
CATH: Paired amphipathic helix 2 (pah2 repeat)
Cerebral cavernous malformations 2 protein in PDB entry 4y5o, assembly 1, front view.
Cerebral cavernous malformations 2 protein in PDB entry 4y5o, assembly 1, side view.
Cerebral cavernous malformations 2 protein in PDB entry 4y5o, assembly 1, top view.
PDBe-KB: UniProt Coverage View: Q9BSQ5  
198102030405060708090
 
50GSKTISESELSASATELLQDYMLTLRTKLSSQEIQQFAALLHEYRNGASIHEFCINLRQLYGDSRKFLLLGLRPFIPEKDSQHFENFLETIGVKDGRG
UniProt
Q9BSQ5
Chains
Domains
Secondary structure
Flexibility predictions
Early folding residue predictions
Interaction interfaces
Sequence conservation
Molecule details ›

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Mitogen-activated protein kinase kinase kinase 3
Chain: B
Length: 126 amino acids
Theoretical weight: 14.68 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: Q99759 (Residues: 1-124; Coverage: 20%)
Gene names: MAP3K3, MAPKKK3, MEKK3
Pfam: PB1 domain
InterPro:
Mitogen-activated protein kinase kinase kinase 3 in PDB entry 4y5o, assembly 1, front view.
Mitogen-activated protein kinase kinase kinase 3 in PDB entry 4y5o, assembly 1, side view.
Mitogen-activated protein kinase kinase kinase 3 in PDB entry 4y5o, assembly 1, top view.
PDBe-KB: UniProt Coverage View: Q99759  
1126102030405060708090100110120
 
50100
UniProt
Q99759
Chains
Domains
Secondary structure
Flexibility predictions
Early folding residue predictions
Interaction interfaces
Molecule details ›

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