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Crystal structure of T. cruzi Histidyl-tRNA synthetase in complex with 3-methoxypyridine (Chem 443)

Source organism: Trypanosoma cruzi strain CL Brener
Biochemical function: ligase activity
Biological process: histidyl-tRNA aminoacylation
Cellular component: cytoplasm

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EC 6.1.1.21: Histidine--tRNA ligase

Reaction catalysed:
ATP + L-histidine + tRNA(His) = AMP + diphosphate + L-histidyl-tRNA(His)
Systematic name:
L-histidine:tRNA(His) ligase (AMP-forming)
Alternative Name(s):
  • Histidine translase
  • Histidyl-tRNA synthetase
  • Histidyl-transfer ribonucleate synthetase

GO terms

Biochemical function:
Biological process:
Cellular component:

Sequence families

Pfam Protein families (Pfam)
PF03129
Domain description: Anticodon binding domain
Occurring in:
  1. histidine--tRNA ligase
The deposited structure of PDB entry 4yrm contains 2 copies of Pfam domain PF03129 (Anticodon binding domain) in histidine--tRNA ligase. Showing 1 copy in chain B.

PF13393
Domain description: Histidyl-tRNA synthetase
Occurring in:
  1. histidine--tRNA ligase
The deposited structure of PDB entry 4yrm contains 2 copies of Pfam domain PF13393 (Histidyl-tRNA synthetase) in histidine--tRNA ligase. Showing 1 copy in chain B.

InterPro InterPro annotations
IPR041715
Domain description: Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain
Occurring in:
  1. histidine--tRNA ligase
IPR045864
Domain description: Class II Aminoacyl-tRNA synthetase/Biotinyl protein ligase (BPL) and lipoyl protein ligase (LPL)
Occurring in:
  1. histidine--tRNA ligase
IPR004516
Domain description: Histidine-tRNA ligase/ATP phosphoribosyltransferase regulatory subunit
Occurring in:
  1. histidine--tRNA ligase
IPR004154
Domain description: Anticodon-binding
Occurring in:
  1. histidine--tRNA ligase
IPR036621
Domain description: Anticodon-binding domain superfamily
Occurring in:
  1. histidine--tRNA ligase
IPR006195
Domain description: Aminoacyl-tRNA synthetase, class II
Occurring in:
  1. histidine--tRNA ligase
IPR015807
Domain description: Histidine-tRNA ligase
Occurring in:
  1. histidine--tRNA ligase

Structure domains

CATH CATH domains
3.40.50.800
Class: Alpha Beta
Architecture: 3-Layer(aba) Sandwich
Topology: Rossmann fold
Homology: Anticodon-binding domain
Occurring in:
  1. histidine--tRNA ligase
The deposited structure of PDB entry 4yrm contains 2 copies of CATH domain 3.40.50.800 (Rossmann fold) in histidine--tRNA ligase. Showing 1 copy in chain B.
3.30.930.10
Class: Alpha Beta
Architecture: 2-Layer Sandwich
Topology: BirA Bifunctional Protein; domain 2
Homology: Bira Bifunctional Protein; Domain 2
Occurring in:
  1. histidine--tRNA ligase
The deposited structure of PDB entry 4yrm contains 2 copies of CATH domain 3.30.930.10 (BirA Bifunctional Protein; domain 2) in histidine--tRNA ligase. Showing 1 copy in chain B.

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