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Crystal structure of T. cruzi Histidyl-tRNA synthetase in complex with 3-methoxypyridine (Chem 443)

X-ray diffraction
2.3Å resolution
PDB entry 4yrm coloured by chain, front view.
PDB entry 4yrm coloured by chain, side view.
PDB entry 4yrm coloured by chain, top view.
Source organism: Trypanosoma cruzi strain CL Brener
Assembly composition:
homo dimer (preferred)
Entry contents: 1 distinct polypeptide molecule

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Assemblies

Assembly 1 (preferred)
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Assembly Name: histidine--tRNA ligase
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Multimeric state: homo dimer
Accessible surface area: 33911.74 Å2
Buried surface area: 9932.06 Å2
Dissociation area: 3,907.62 Å2
Dissociation energy (ΔGdiss): 55.08 kcal/mol
Dissociation entropy (TΔSdiss): 15.4 kcal/mol
Symmetry number: 2
PDBe Complex ID: PDB-CPX-175465

Macromolecules

histidine--tRNA ligase
Chains: A, B
Length: 456 amino acids
Theoretical weight: 51.19 KDa
Source organism: Trypanosoma cruzi strain CL Brener
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: Q4DA54 (Residues: 45-478; Coverage: 91%)
Gene name: Tc00.1047053507019.40
Pfam:
InterPro:
CATH:
histidine--tRNA ligase in PDB entry 4yrm, assembly 1, front view.
histidine--tRNA ligase in PDB entry 4yrm, assembly 1, side view.
histidine--tRNA ligase in PDB entry 4yrm, assembly 1, top view.
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