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Crystal structure of RPE65 in complex with MB-002

X-ray diffraction
2.09Å resolution
PDB entry 4zhk coloured by chain, front view.
PDB entry 4zhk coloured by chain, side view.
PDB entry 4zhk coloured by chain, top view.
Source organism: Bos taurus
Assembly composition:
homo dimer (preferred)
Entry contents: 1 distinct polypeptide molecule

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Assemblies

Assembly 1 (preferred)
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Assembly Name: Retinoid isomerohydrolase
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Multimeric state: homo dimer
Accessible surface area: 36414.71 Å2
Buried surface area: 5665.17 Å2
Dissociation area: 1,565.84 Å2
Dissociation energy (ΔGdiss): 7.19 kcal/mol
Dissociation entropy (TΔSdiss): 14.75 kcal/mol
Symmetry number: 2
PDBe Complex ID: PDB-CPX-173309

Macromolecules

Retinoid isomerohydrolase
Chains: A, B
Length: 533 amino acids
Theoretical weight: 60.94 KDa
Source organism: Bos taurus
UniProt:
  • Canonical: Q28175 (Residues: 2-533; Coverage: 100%)
Gene name: RPE65
Pfam: Retinal pigment epithelial membrane protein
InterPro: Carotenoid oxygenase
Retinoid isomerohydrolase in PDB entry 4zhk, assembly 1, front view.
Retinoid isomerohydrolase in PDB entry 4zhk, assembly 1, side view.
Retinoid isomerohydrolase in PDB entry 4zhk, assembly 1, top view.
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