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Crystal Structure of Keap1 in Complex with a small chemical compound, K67

X-ray diffraction
1.8Å resolution
PDB entry 4zy3 coloured by chain, front view.
PDB entry 4zy3 coloured by chain, side view.
PDB entry 4zy3 coloured by chain, top view.
Source organism: Mus musculus
Assembly composition:
monomeric (preferred)
Entry contents: 1 distinct polypeptide molecule

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Assemblies

Assembly 1 (preferred)
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Assembly Name: Kelch-like ECH-associated protein 1
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Multimeric state: monomeric
Accessible surface area: 11758.58 Å2
Buried surface area: 87.89 Å2
Dissociation area: 43.94 Å2
Dissociation energy (ΔGdiss): 2.17 kcal/mol
Dissociation entropy (TΔSdiss): -1.35 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-195563
Assembly 2
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Assembly Name: Kelch-like ECH-associated protein 1
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Multimeric state: monomeric
Accessible surface area: 11681.95 Å2
Buried surface area: 169.12 Å2
Dissociation area: 84.56 Å2
Dissociation energy (ΔGdiss): 2.7 kcal/mol
Dissociation entropy (TΔSdiss): -1.34 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-195563

Macromolecules

Kelch-like ECH-associated protein 1
Chains: A, B
Length: 311 amino acids
Theoretical weight: 34.27 KDa
Source organism: Mus musculus
Expression system: Escherichia coli
UniProt:
  • Canonical: Q9Z2X8 (Residues: 321-609; Coverage: 46%)
Gene names: Inrf2, Keap1, Kiaa0132
Pfam: Kelch motif
InterPro:
CATH: Kelch-type beta propeller
Kelch-like ECH-associated protein 1 in PDB entry 4zy3, assembly 1, front view.
Kelch-like ECH-associated protein 1 in PDB entry 4zy3, assembly 1, side view.
Kelch-like ECH-associated protein 1 in PDB entry 4zy3, assembly 1, top view.
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