› 5z4p

X-ray diffraction
2.5Å resolution

Crystal structure of tubulin-stathmin-TTL-Compound TCA complex

Released:
DOI: 10.2210/pdb5z4p/pdb
PDB entry 5z4p coloured by chain, front view.
PDB entry 5z4p coloured by chain, side view.
PDB entry 5z4p coloured by chain, top view.
Source organisms:
Entry authors: Zhang H, Luo C

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
hetero hexamer (preferred)
PDBe Complex ID:
PDB-CPX-549401 (preferred)
Entry contents:
4 distinct polypeptide molecules
Macromolecules (4 distinct):
Tubulin alpha-1B chain Chains: A, C
Molecule details ›
Chains: A, C
Length: 440 amino acids
Theoretical weight: 48.97 KDa
Source organism: Bos taurus
UniProt:
  • Canonical: P81947 (Residues: 1-440; Coverage: 98%)
Sequence domains:
Structure domains:
Tubulin beta-2B chain Chains: B, D
Molecule details ›
Chains: B, D
Length: 431 amino acids
Theoretical weight: 48.39 KDa
Source organism: Bos taurus
UniProt:
  • Canonical: Q6B856 (Residues: 1-431; Coverage: 97%)
Gene name: TUBB2B
Sequence domains:
Structure domains:
Stathmin-4 Chain: E
Molecule details ›
Chain: E
Length: 185 amino acids
Theoretical weight: 21.68 KDa
Source organism: Rattus norvegicus
UniProt:
  • Canonical: P63043 (Residues: 1-185; Coverage: 98%)
Gene name: Stmn4
Sequence domains: Stathmin family
Structure domains: Methane Monooxygenase Hydroxylase; Chain G, domain 1
Tubulin tyrosine ligase Chain: F
Molecule details ›
Chain: F
Length: 378 amino acids
Theoretical weight: 43.55 KDa
Source organism: Gallus gallus
Structure domains:

Ligands and Environments

9 bound ligands:
Ligand GTP 2 x GTP
Ligand MG 4 x MG
Ligand GOL 11 x GOL
Ligand CA 3 x CA
Ligand GDP 2 x GDP
Ligand MES 1 x MES
Ligand 97O 1 x 97O
Ligand IMD 3 x IMD
Ligand ACP 1 x ACP
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SSRF BEAMLINE BL19U1
Spacegroup: P212121
Unit cell:
a: 103.832Å b: 154.843Å c: 181.024Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.222 0.222 0.286

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