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Crystal structure of tubulin-stathmin-TTL-Compound TCA complex

X-ray diffraction
2.5Å resolution
PDB entry 5z4p coloured by chain, front view.
PDB entry 5z4p coloured by chain, side view.
PDB entry 5z4p coloured by chain, top view.
Source organisms:
Assembly composition:
hetero hexamer (preferred)
Entry contents: 4 distinct polypeptide molecules

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Assemblies

Assembly 1 (preferred)
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Multimeric state: hetero hexamer
Accessible surface area: 77500.32 Å2
Buried surface area: 25909.74 Å2
Dissociation area: 1,128.24 Å2
Dissociation energy (ΔGdiss): -6.19 kcal/mol
Dissociation entropy (TΔSdiss): 14.6 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-237157

Macromolecules

Tubulin alpha-1B chain
Chains: A, C
Length: 440 amino acids
Theoretical weight: 48.97 KDa
Source organism: Bos taurus
UniProt:
  • Canonical: P81947 (Residues: 1-440; Coverage: 98%)
Pfam:
InterPro:
CATH:
Tubulin alpha-1B chain in PDB entry 5z4p, assembly 1, front view.
Tubulin alpha-1B chain in PDB entry 5z4p, assembly 1, side view.
Tubulin alpha-1B chain in PDB entry 5z4p, assembly 1, top view.
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Tubulin beta-2B chain
Chains: B, D
Length: 431 amino acids
Theoretical weight: 48.39 KDa
Source organism: Bos taurus
UniProt:
  • Canonical: Q6B856 (Residues: 1-431; Coverage: 97%)
Gene name: TUBB2B
Pfam:
InterPro:
CATH:
Tubulin beta-2B chain in PDB entry 5z4p, assembly 1, front view.
Tubulin beta-2B chain in PDB entry 5z4p, assembly 1, side view.
Tubulin beta-2B chain in PDB entry 5z4p, assembly 1, top view.
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Stathmin-4
Chain: E
Length: 185 amino acids
Theoretical weight: 21.68 KDa
Source organism: Rattus norvegicus
UniProt:
  • Canonical: P63043 (Residues: 1-185; Coverage: 98%)
Gene name: Stmn4
Pfam: Stathmin family
InterPro:
CATH: Methane Monooxygenase Hydroxylase; Chain G, domain 1
Stathmin-4 in PDB entry 5z4p, assembly 1, front view.
Stathmin-4 in PDB entry 5z4p, assembly 1, side view.
Stathmin-4 in PDB entry 5z4p, assembly 1, top view.
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Tubulin tyrosine ligase
Chain: F
Length: 378 amino acids
Theoretical weight: 43.55 KDa
Source organism: Gallus gallus
InterPro: Tubulin-tyrosine ligase/Tubulin polyglutamylase
CATH:
TTL ligase in PDB entry 5z4p, assembly 1, front view.
TTL ligase in PDB entry 5z4p, assembly 1, side view.
TTL ligase in PDB entry 5z4p, assembly 1, top view.
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