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Crystal structure of an Fab against human influenza A

X-ray diffraction
2.4Å resolution
PDB entry 5b4m coloured by chain, front view.
PDB entry 5b4m coloured by chain, side view.
PDB entry 5b4m coloured by chain, top view.
Source organism: Mus musculus
Assembly composition:
hetero dimer (preferred)
Entry contents: 2 distinct polypeptide molecules

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Assemblies

Assembly 1 (preferred)
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Assembly Name: IG-heavy chain and IG-light kappa chain
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Multimeric state: hetero dimer
Accessible surface area: 19787.4 Å2
Buried surface area: 3805.87 Å2
Dissociation area: 1,902.93 Å2
Dissociation energy (ΔGdiss): 16.95 kcal/mol
Dissociation entropy (TΔSdiss): 13.2 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-213682
Assembly 2
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Assembly Name: IG-heavy chain and IG-light kappa chain
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Multimeric state: hetero dimer
Accessible surface area: 19891.53 Å2
Buried surface area: 3915.05 Å2
Dissociation area: 1,957.53 Å2
Dissociation energy (ΔGdiss): 17.75 kcal/mol
Dissociation entropy (TΔSdiss): 13.22 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-213682

Macromolecules

Fab heavy chain
Chains: C, H
Length: 221 amino acids
Theoretical weight: 23.99 KDa
Source organism: Mus musculus
InterPro:
CATH: Immunoglobulins
Fab heavy chain in PDB entry 5b4m, assembly 1, front view.
Fab heavy chain in PDB entry 5b4m, assembly 1, side view.
Fab heavy chain in PDB entry 5b4m, assembly 1, top view.
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Fab light chain
Chains: D, L
Length: 218 amino acids
Theoretical weight: 23.93 KDa
Source organism: Mus musculus
InterPro:
CATH: Immunoglobulins
Fab light chain in PDB entry 5b4m, assembly 1, front view.
Fab light chain in PDB entry 5b4m, assembly 1, side view.
Fab light chain in PDB entry 5b4m, assembly 1, top view.
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