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Human insulin with intra-chain chemical crosslink between modified B27 and B30

X-ray diffraction
1.54Å resolution
PDB entry 5bqq coloured by chain, front view.
PDB entry 5bqq coloured by chain, side view.
PDB entry 5bqq coloured by chain, top view.
Source organism: Homo sapiens
Assembly composition:
hetero dodecamer (preferred)
Entry contents: 2 distinct polypeptide molecules

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Assemblies

Assembly 1 (preferred)
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Assembly Name: Insulin B chain
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Multimeric state: hetero dodecamer
Accessible surface area: 11837.54 Å2
Buried surface area: 21401.47 Å2
Dissociation area: 348.61 Å2
Dissociation energy (ΔGdiss): 87.8 kcal/mol
Dissociation entropy (TΔSdiss): 2.21 kcal/mol
Symmetry number: 6
PDBe Complex ID: PDB-CPX-134235

Macromolecules

Insulin A chain
Chains: A, C, E, G, I, K
Length: 21 amino acids
Theoretical weight: 2.38 KDa
Source organism: Homo sapiens
Expression system: Not provided
UniProt:
  • Canonical: P01308 (Residues: 90-110; Coverage: 24%)
Gene name: INS
InterPro:
Insulin A chain in PDB entry 5bqq, assembly 1, front view.
Insulin A chain in PDB entry 5bqq, assembly 1, side view.
Insulin A chain in PDB entry 5bqq, assembly 1, top view.
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Insulin B chain
Chains: B, D, F, H, J, L
Length: 30 amino acids
Theoretical weight: 3.4 KDa
Source organism: Homo sapiens
Expression system: Not provided
UniProt:
  • Canonical: P01308 (Residues: 25-52; Coverage: 33%)
Gene name: INS
InterPro:
Insulin B chain in PDB entry 5bqq, assembly 1, front view.
Insulin B chain in PDB entry 5bqq, assembly 1, side view.
Insulin B chain in PDB entry 5bqq, assembly 1, top view.
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