EC 2.6.1.42: Branched-chain-amino-acid transaminase
Reaction catalysed:
L-leucine + 2-oxoglutarate = 4-methyl-2-oxopentanoate + L-glutamate
Systematic name:
Branched-chain-amino-acid:2-oxoglutarate aminotransferase
Alternative Name(s):
- Branched-chain amino acid aminotransferase
- Branched-chain amino acid--glutamate transaminase
- Branched-chain aminotransferase
- Glutamate--branched-chain amino acid transaminase
- L-branched chain amino acid aminotransferase
- Transaminase B
GO terms
Biochemical function:
Biological process:
- cellular response to leukemia inhibitory factor
- regulation of hormone levels
- valine biosynthetic process
- L-leucine biosynthetic process
- branched-chain amino acid catabolic process
- branched-chain amino acid biosynthetic process
- branched-chain amino acid metabolic process
- amino acid biosynthetic process
- lipid metabolic process
- valine metabolic process
- L-leucine metabolic process
- isoleucine catabolic process
- isoleucine metabolic process
Cellular component:
Sequence family
Protein family (Pfam)
InterPro annotations
IPR043132
Domain description:
Branched-chain-amino-acid aminotransferase-like, C-terminal
Occurring in:
Occurring in:
Structure domains
CATH domains
3.30.470.10
Class:
Alpha Beta
Architecture:
2-Layer Sandwich
Topology:
D-amino Acid Aminotransferase; Chain A, domain 1
Homology:
D-amino Acid Aminotransferase; Chain A, domain 1
Occurring in:
![The deposited structure of PDB entry <span class='highlight'>5bwv</span> contains 2 copies of CATH domain <span class='highlight'>3.30.470.10 (D-amino Acid Aminotransferase; Chain A, domain 1)</span> in <span class='highlight'>Branched-chain-amino-acid aminotransferase, mitochondrial</span>. Showing 1 copy in chain <span class='highlight'>B</span>. The deposited structure of PDB entry 5bwv contains 2 copies of CATH domain 3.30.470.10 (D-amino Acid Aminotransferase; Chain A, domain 1) in Branched-chain-amino-acid aminotransferase, mitochondrial. Showing 1 copy in chain B.](https://www.ebi.ac.uk/pdbe/static/entry/5bwv_1_B_CATH_3.30.470.10_image-200x200.png)