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X-RAY CRYSTAL STRUCTURE AT 1.86A RESOLUTION OF HUMAN MITOCHONDRIAL BRANCHED CHAIN AMINOTRANSFERASE (BCATM) COMPLEXED WITH A PYRAZOLOPYRIMIDINONE COMPOUND AND AN INTERNAL ALDIMINE LINKED PLP COFACTOR.

X-ray diffraction
1.86Å resolution
PDB entry 5bwv coloured by chain, front view.
PDB entry 5bwv coloured by chain, side view.
PDB entry 5bwv coloured by chain, top view.
Source organism: Homo sapiens
Assembly composition:
homo dimer (preferred)
Entry contents: 1 distinct polypeptide molecule

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Assemblies

Assembly 1 (preferred)
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Assembly Name: Branched-chain-amino-acid aminotransferase, mitochondrial
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Multimeric state: homo dimer
Accessible surface area: 26543.08 Å2
Buried surface area: 9924.58 Å2
Dissociation area: 2,701.67 Å2
Dissociation energy (ΔGdiss): 22.5 kcal/mol
Dissociation entropy (TΔSdiss): 14.43 kcal/mol
Symmetry number: 2
PDBe Complex ID: PDB-CPX-127454

Macromolecules

Branched-chain-amino-acid aminotransferase, mitochondrial
Chains: A, B
Length: 369 amino acids
Theoretical weight: 41.73 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: O15382 (Residues: 28-392; Coverage: 93%)
Gene names: BCAT2, BCATM, BCT2, ECA40
Pfam: Amino-transferase class IV
InterPro:
CATH:
Branched-chain-amino-acid aminotransferase, mitochondrial in PDB entry 5bwv, assembly 1, front view.
Branched-chain-amino-acid aminotransferase, mitochondrial in PDB entry 5bwv, assembly 1, side view.
Branched-chain-amino-acid aminotransferase, mitochondrial in PDB entry 5bwv, assembly 1, top view.
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