Structure analysis

X-ray structure of the complex between human alpha thrombin and a duplex/quadruplex 31-mer DNA aptamer

X-ray diffraction
2.98Å resolution
Source organism: Homo sapiens
Assembly composition:
hetero trimer (preferred)
Entry contents: 2 distinct polypeptide molecules
1 distinct DNA molecule

Assemblies

Assembly 1 (preferred)
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Multimeric state: hetero trimer
Accessible surface area: 16893.75 Å2
Buried surface area: 3399.95 Å2
Dissociation area: 551.66 Å2
Dissociation energy (ΔGdiss): -0.39 kcal/mol
Dissociation entropy (TΔSdiss): 11.18 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-118503

Macromolecules

Chain: L
Length: 36 amino acids
Theoretical weight: 4.1 KDa
Source organism: Homo sapiens
UniProt:
  • Canonical: P00734 (Residues: 328-363; Coverage: 6%)
Gene name: F2
Pfam: Thrombin light chain
InterPro:

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Name: RE31
Representative chains: A
Length: 31 nucleotides
Theoretical weight: 9.73 KDa

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