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Crystal Structure of sErbB3-Fab3379 Complex

X-ray diffraction
3.2Å resolution
PDB entry 5cus coloured by chain, front view.
PDB entry 5cus coloured by chain, side view.
PDB entry 5cus coloured by chain, top view.
Source organism: Homo sapiens
Assembly composition:
hetero trimer (preferred)
Entry contents: 3 distinct polypeptide molecules

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Assemblies

Assembly 1 (preferred)
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Multimeric state: hetero trimer
Accessible surface area: 43299.35 Å2
Buried surface area: 5443.76 Å2
Dissociation area: 954.26 Å2
Dissociation energy (ΔGdiss): -3.35 kcal/mol
Dissociation entropy (TΔSdiss): 14.25 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-229914
Assembly 2
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Multimeric state: hetero trimer
Accessible surface area: 43861.91 Å2
Buried surface area: 5470.81 Å2
Dissociation area: 924.22 Å2
Dissociation energy (ΔGdiss): 0.75 kcal/mol
Dissociation entropy (TΔSdiss): 14.26 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-229914
Assembly 3
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Multimeric state: hetero trimer
Accessible surface area: 43286.76 Å2
Buried surface area: 4961.92 Å2
Dissociation area: 969.99 Å2
Dissociation energy (ΔGdiss): -1.68 kcal/mol
Dissociation entropy (TΔSdiss): 14.16 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-229914
Assembly 4
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Multimeric state: hetero trimer
Accessible surface area: 44830.31 Å2
Buried surface area: 5110.54 Å2
Dissociation area: 936.38 Å2
Dissociation energy (ΔGdiss): -4.39 kcal/mol
Dissociation entropy (TΔSdiss): 14.16 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-229914

Macromolecules

Receptor tyrosine-protein kinase erbB-3
Chains: A, B, C, D
Length: 627 amino acids
Theoretical weight: 69.22 KDa
Source organism: Homo sapiens
Expression system: Spodoptera frugiperda
UniProt:
  • Canonical: P21860 (Residues: 20-641; Coverage: 47%)
  • Best match: P21860-3 (Residues: 20-330)
Gene names: ERBB3, HER3
Pfam:
InterPro:
CATH:
Receptor tyrosine-protein kinase erbB-3 in PDB entry 5cus, assembly 1, front view.
Receptor tyrosine-protein kinase erbB-3 in PDB entry 5cus, assembly 1, side view.
Receptor tyrosine-protein kinase erbB-3 in PDB entry 5cus, assembly 1, top view.
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Ig-like domain-containing protein
Chains: H, I, J, K
Length: 221 amino acids
Theoretical weight: 23.35 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: S6B291 (Residues: 20-116, 117-239; Coverage: 49%)
Pfam:
InterPro:
CATH: Immunoglobulins
Ig-like domain-containing protein in PDB entry 5cus, assembly 1, front view.
Ig-like domain-containing protein in PDB entry 5cus, assembly 1, side view.
Ig-like domain-containing protein in PDB entry 5cus, assembly 1, top view.
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Fab LC region of KTN3379
Chains: L, M, N, O
Length: 216 amino acids
Theoretical weight: 22.73 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
InterPro:
CATH: Immunoglobulins
Fab LC region of KTN3379 in PDB entry 5cus, assembly 1, front view.
Fab LC region of KTN3379 in PDB entry 5cus, assembly 1, side view.
Fab LC region of KTN3379 in PDB entry 5cus, assembly 1, top view.
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