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Crystal structure of GASDALIE IgG1 Fc in complex with FcgRIIIa

X-ray diffraction
3.13Å resolution
PDB entry 5d6d coloured by chain, front view.
PDB entry 5d6d coloured by chain, side view.
PDB entry 5d6d coloured by chain, top view.
Source organism: Homo sapiens
Assembly composition:
hetero trimer (preferred)
Entry contents: 2 distinct polypeptide molecules

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Assemblies

Assembly 1 (preferred)
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Assembly Name: Low affinity immunoglobulin gamma Fc region receptor III-A and IG-heavy chain
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Multimeric state: hetero trimer
Accessible surface area: 29275.19 Å2
Buried surface area: 9893.47 Å2
Dissociation area: 871.21 Å2
Dissociation energy (ΔGdiss): -6.66 kcal/mol
Dissociation entropy (TΔSdiss): 12.33 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-134854

Macromolecules

Immunoglobulin heavy constant gamma 1
Chains: A, B
Length: 249 amino acids
Theoretical weight: 28.11 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
  • Canonical: P01857 (Residues: 108-328; Coverage: 55%)
  • Best match: P01857-1 (Residues: 108-329)
Gene name: IGHG1
Pfam: Immunoglobulin C1-set domain
InterPro:
CATH: Immunoglobulins
Immunoglobulin heavy constant gamma 1 in PDB entry 5d6d, assembly 1, front view.
Immunoglobulin heavy constant gamma 1 in PDB entry 5d6d, assembly 1, side view.
Immunoglobulin heavy constant gamma 1 in PDB entry 5d6d, assembly 1, top view.
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Low affinity immunoglobulin gamma Fc region receptor III-A
Chain: C
Length: 240 amino acids
Theoretical weight: 27.09 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
  • Canonical: P08637 (Residues: 14-205; Coverage: 79%)
Gene names: CD16A, FCG3, FCGR3, FCGR3A, IGFR3
Pfam: Immunoglobulin domain
InterPro:
CATH: Immunoglobulins
Low affinity immunoglobulin gamma Fc region receptor III-A in PDB entry 5d6d, assembly 1, front view.
Low affinity immunoglobulin gamma Fc region receptor III-A in PDB entry 5d6d, assembly 1, side view.
Low affinity immunoglobulin gamma Fc region receptor III-A in PDB entry 5d6d, assembly 1, top view.
Molecule details ›

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