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Aurora A Kinase in Complex with AA35 and ATP in Space Group P6122

X-ray diffraction
2.98Å resolution
PDB entry 5dos coloured by chain, front view.
PDB entry 5dos coloured by chain, side view.
PDB entry 5dos coloured by chain, top view.
Source organism: Homo sapiens
Assembly composition:
monomeric (preferred)
Entry contents: 1 distinct polypeptide molecule

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Assemblies

Assembly 1 (preferred)
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Assembly Name: Aurora kinase A
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Multimeric state: monomeric
Accessible surface area: 12221.44 Å2
Buried surface area: 1051.14 Å2
Dissociation area: 75.69 Å2
Dissociation energy (ΔGdiss): 12.06 kcal/mol
Dissociation entropy (TΔSdiss): -1.46 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-127232

Macromolecules

Aurora kinase A
Chain: A
Length: 273 amino acids
Theoretical weight: 31.81 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: O14965 (Residues: 126-390; Coverage: 66%)
Gene names: AIK, AIRK1, ARK1, AURA, AURKA, AYK1, BTAK, IAK1, STK15, STK6
Pfam: Protein kinase domain
InterPro:
CATH:
Aurora kinase A in PDB entry 5dos, assembly 1, front view.
Aurora kinase A in PDB entry 5dos, assembly 1, side view.
Aurora kinase A in PDB entry 5dos, assembly 1, top view.
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