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TGF-BETA RECEPTOR TYPE 1 KINASE DOMAIN (T204D,I211V,Y249F, S280T,Y282F,S287N,A350C,L352F) IN COMPLEX WITH 3-AMINO-6- [4-(2-HYDROXYETHYL)PHENYL]-N-[4-(MORPHOLIN-4-YL)PYRIDIN-3-YL]PYRAZINE-2-CARBOXAMIDE

X-ray diffraction
2.05Å resolution
PDB entry 5e90 coloured by chain, front view.
PDB entry 5e90 coloured by chain, side view.
PDB entry 5e90 coloured by chain, top view.
Source organism: Homo sapiens
Assembly composition:
monomeric (preferred)
Entry contents: 1 distinct polypeptide molecule

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Assemblies

Assembly 1 (preferred)
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Assembly Name: TGF-beta receptor type-1
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Multimeric state: monomeric
Accessible surface area: 14102.94 Å2
Buried surface area: 0.0 Å2
Dissociation area: 0 Å2
Dissociation energy (ΔGdiss): 0 kcal/mol
Dissociation entropy (TΔSdiss): 0 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-153250

Macromolecules

TGF-beta receptor type-1
Chain: A
Length: 307 amino acids
Theoretical weight: 35.23 KDa
Source organism: Homo sapiens
Expression system: Spodoptera frugiperda
UniProt:
  • Canonical: P36897 (Residues: 200-503; Coverage: 65%)
Gene names: ALK5, SKR4, TGFBR1
Pfam: Protein kinase domain
InterPro:
CATH:
TGF-beta receptor type-1 in PDB entry 5e90, assembly 1, front view.
TGF-beta receptor type-1 in PDB entry 5e90, assembly 1, side view.
TGF-beta receptor type-1 in PDB entry 5e90, assembly 1, top view.
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