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Crystal structure of OPTN E50K mutant and TBK1 complex

X-ray diffraction
2.503Å resolution
PDB entry 5eoa coloured by chain, front view.
PDB entry 5eoa coloured by chain, side view.
PDB entry 5eoa coloured by chain, top view.
Source organism: Homo sapiens
Assembly composition:
hetero tetramer (preferred)
Entry contents: 2 distinct polypeptide molecules

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Assemblies

Assembly 1 (preferred)
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Assembly Name: Optineurin and Serine/threonine-protein kinase TBK1
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Multimeric state: hetero tetramer
Accessible surface area: 13699.26 Å2
Buried surface area: 9774.23 Å2
Dissociation area: 2,039.58 Å2
Dissociation energy (ΔGdiss): 35.81 kcal/mol
Dissociation entropy (TΔSdiss): 10.82 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-572288

Macromolecules

Optineurin
Chains: A, B
Length: 82 amino acids
Theoretical weight: 9.65 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: Q96CV9 (Residues: 26-103; Coverage: 14%)
  • Best match: Q96CV9-3 (Residues: 1-46)
Gene names: FIP2, GLC1E, HIP7, HYPL, NRP, OPTN
Pfam: NF-kappa-B essential modulator NEMO
InterPro: NF-kappa-B essential modulator NEMO, N-terminal
Optineurin in PDB entry 5eoa, assembly 1, front view.
Optineurin in PDB entry 5eoa, assembly 1, side view.
Optineurin in PDB entry 5eoa, assembly 1, top view.
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Serine/threonine-protein kinase TBK1
Chains: C, D
Length: 57 amino acids
Theoretical weight: 6.25 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: Q9UHD2 (Residues: 677-729; Coverage: 7%)
Gene names: NAK, TBK1
Serine/threonine-protein kinase TBK1 in PDB entry 5eoa, assembly 1, front view.
Serine/threonine-protein kinase TBK1 in PDB entry 5eoa, assembly 1, side view.
Serine/threonine-protein kinase TBK1 in PDB entry 5eoa, assembly 1, top view.
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