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Crystal Structure of chromodomain of CBX2 in complex with inhibitor UNC3866

X-ray diffraction
1.8Å resolution
PDB entry 5epk coloured by chain, front view.
PDB entry 5epk coloured by chain, side view.
PDB entry 5epk coloured by chain, top view.
Source organism: Homo sapiens
Assembly composition:
hetero dimer (preferred)
Entry contents: 2 distinct polypeptide molecules

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Assemblies

Assembly 1 (preferred)
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Assembly Name: Chromobox protein homolog 2 and peptide
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Multimeric state: hetero dimer
Accessible surface area: 4205.01 Å2
Buried surface area: 1414.54 Å2
Dissociation area: 707.27 Å2
Dissociation energy (ΔGdiss): 2.52 kcal/mol
Dissociation entropy (TΔSdiss): 6.67 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-165610

Macromolecules

Chromobox protein homolog 2
Chain: A
Length: 55 amino acids
Theoretical weight: 6.57 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: Q14781 (Residues: 8-62; Coverage: 10%)
Gene name: CBX2
Pfam: Chromo (CHRromatin Organisation MOdifier) domain
InterPro:
CATH: OB fold (Dihydrolipoamide Acetyltransferase, E2P)
Chromobox protein homolog 2 in PDB entry 5epk, assembly 1, front view.
Chromobox protein homolog 2 in PDB entry 5epk, assembly 1, side view.
Chromobox protein homolog 2 in PDB entry 5epk, assembly 1, top view.
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unc3866
Chain: B
Length: 6 amino acids
Theoretical weight: 795 Da
Source organism: Homo sapiens
Expression system: Not provided
unc3866 in PDB entry 5epk, assembly 1, front view.
unc3866 in PDB entry 5epk, assembly 1, side view.
unc3866 in PDB entry 5epk, assembly 1, top view.
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