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Crystal structure of ChREBP:14-3-3 complex bound with AMP

X-ray diffraction
2.35Å resolution
PDB entry 5f74 coloured by chain, front view.
PDB entry 5f74 coloured by chain, side view.
PDB entry 5f74 coloured by chain, top view.
Source organisms:
Assemblies composition:
hetero dimer (preferred)
hetero octamer
Entry contents: 2 distinct polypeptide molecules

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Assemblies

Assembly 1 (preferred)
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Assembly Name: Carbohydrate-responsive element-binding protein and 14-3-3 protein beta/alpha
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Multimeric state: hetero dimer
Accessible surface area: 12967.94 Å2
Buried surface area: 2371.1 Å2
Dissociation area: 1,085.7 Å2
Dissociation energy (ΔGdiss): 2.4 kcal/mol
Dissociation entropy (TΔSdiss): 9.5 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-186595
Assembly 2
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Assembly Name: Carbohydrate-responsive element-binding protein and 14-3-3 protein beta/alpha
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Multimeric state: hetero octamer
Accessible surface area: 45112.88 Å2
Buried surface area: 16242.57 Å2
Dissociation area: 1,296.51 Å2
Dissociation energy (ΔGdiss): 3.5 kcal/mol
Dissociation entropy (TΔSdiss): 14.65 kcal/mol
Symmetry number: 4
PDBe Complex ID: PDB-CPX-186596

Macromolecules

14-3-3 protein beta/alpha
Chain: A
Length: 246 amino acids
Theoretical weight: 28.12 KDa
Source organism: Mus musculus
Expression system: Escherichia coli
UniProt:
  • Canonical: Q9CQV8 (Residues: 1-246; Coverage: 100%)
Gene name: Ywhab
Pfam: 14-3-3 protein
InterPro:
CATH: 14-3-3 domain
14-3-3 protein beta/alpha in PDB entry 5f74, assembly 1, front view.
14-3-3 protein beta/alpha in PDB entry 5f74, assembly 1, side view.
14-3-3 protein beta/alpha in PDB entry 5f74, assembly 1, top view.
PDBe-KB: UniProt Coverage View: Q9CQV8  
124620406080100120140160180200220240
 
100200
UniProt
Q9CQV8
Chains
Domains
Secondary structure
Flexibility predictions
Early folding residue predictions
Ligand binding sites
Interaction interfaces
Sequence conservation
Molecule details ›

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Carbohydrate-responsive element-binding protein
Chain: B
Length: 196 amino acids
Theoretical weight: 22.66 KDa
Source organism: Rattus norvegicus
Expression system: Escherichia coli
UniProt:
  • Canonical: Q8VIP2 (Residues: 1-196; Coverage: 23%)
Gene names: Mlxipl, Wbscr14
Carbohydrate-responsive element-binding protein in PDB entry 5f74, assembly 1, front view.
Carbohydrate-responsive element-binding protein in PDB entry 5f74, assembly 1, side view.
Carbohydrate-responsive element-binding protein in PDB entry 5f74, assembly 1, top view.
PDBe-KB: UniProt Coverage View: Q8VIP2  
119620406080100120140160180
 
50100150
UniProt
Q8VIP2
Chains
Secondary structure
Flexibility predictions
Early folding residue predictions
Ligand binding sites
Interaction interfaces
Sequence conservation
Molecule details ›

Search similar proteins

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