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Architecture of human mTOR Complex 1 - 5.9 Angstrom reconstruction

Electron Microscopy
5.9Å resolution
PDB entry 5flc coloured by chain, front view.
PDB entry 5flc coloured by chain, side view.
PDB entry 5flc coloured by chain, top view.
Source organisms:
Assembly composition:
hetero dodecamer (preferred)
Entry contents: 6 distinct polypeptide molecules

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Assemblies

Assembly 1 (preferred)
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Multimeric state: hetero dodecamer
Accessible surface area: 346253.83 Å2
Buried surface area: 17295.03 Å2
Dissociation area: 7,915.75 Å2
Dissociation energy (ΔGdiss): -93.29 kcal/mol
Dissociation entropy (TΔSdiss): 164.55 kcal/mol
Symmetry number: 2
PDBe Complex ID: PDB-CPX-154629

Macromolecules

SERINE/THREONINE-PROTEIN KINASE MTOR
Chains: 1, 3
Length: 615 amino acids
Theoretical weight: 52.36 KDa
Source organism: Homo sapiens
Expression system: Spodoptera frugiperda
SERINE/THREONINE-PROTEIN KINASE MTOR in PDB entry 5flc, assembly 1, front view.
SERINE/THREONINE-PROTEIN KINASE MTOR in PDB entry 5flc, assembly 1, side view.
SERINE/THREONINE-PROTEIN KINASE MTOR in PDB entry 5flc, assembly 1, top view.
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SERINE/THREONINE-PROTEIN KINASE MTOR
Chains: 2, 4
Length: 365 amino acids
Theoretical weight: 31.08 KDa
Source organism: Homo sapiens
Expression system: Spodoptera frugiperda
SERINE/THREONINE-PROTEIN KINASE MTOR in PDB entry 5flc, assembly 1, front view.
SERINE/THREONINE-PROTEIN KINASE MTOR in PDB entry 5flc, assembly 1, side view.
SERINE/THREONINE-PROTEIN KINASE MTOR in PDB entry 5flc, assembly 1, top view.
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REGULATORY-ASSOCIATED PROTEIN OF MTOR
Chains: A, E
Length: 1029 amino acids
Theoretical weight: 87.59 KDa
Source organism: Homo sapiens
Expression system: Spodoptera frugiperda
REGULATORY-ASSOCIATED PROTEIN OF MTOR in PDB entry 5flc, assembly 1, front view.
REGULATORY-ASSOCIATED PROTEIN OF MTOR in PDB entry 5flc, assembly 1, side view.
REGULATORY-ASSOCIATED PROTEIN OF MTOR in PDB entry 5flc, assembly 1, top view.
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Serine/threonine-protein kinase mTOR
Chains: B, F
Length: 1168 amino acids
Theoretical weight: 134.04 KDa
Source organism: Homo sapiens
Expression system: Spodoptera frugiperda
UniProt:
  • Canonical: P42345 (Residues: 1382-2549; Coverage: 46%)
Gene names: FRAP, FRAP1, FRAP2, MTOR, RAFT1, RAPT1
Pfam:
InterPro:
Serine/threonine-protein kinase mTOR in PDB entry 5flc, assembly 1, front view.
Serine/threonine-protein kinase mTOR in PDB entry 5flc, assembly 1, side view.
Serine/threonine-protein kinase mTOR in PDB entry 5flc, assembly 1, top view.
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FKBP
Chains: C, G
Length: 107 amino acids
Theoretical weight: 9.12 KDa
Source organism: Spodoptera frugiperda
FKBP in PDB entry 5flc, assembly 1, front view.
FKBP in PDB entry 5flc, assembly 1, side view.
FKBP in PDB entry 5flc, assembly 1, top view.
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Target of rapamycin complex subunit LST8
Chains: D, H
Length: 326 amino acids
Theoretical weight: 35.91 KDa
Source organism: Homo sapiens
Expression system: Spodoptera frugiperda
UniProt:
  • Canonical: Q9BVC4 (Residues: 1-326; Coverage: 100%)
Gene names: GBL, LST8, MLST8
Pfam: WD domain, G-beta repeat
InterPro:
Target of rapamycin complex subunit LST8 in PDB entry 5flc, assembly 1, front view.
Target of rapamycin complex subunit LST8 in PDB entry 5flc, assembly 1, side view.
Target of rapamycin complex subunit LST8 in PDB entry 5flc, assembly 1, top view.
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