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Crystal structure of human tankyrase 2 in complex with TA-92

X-ray diffraction
2.75Å resolution
PDB entry 5fpg coloured by chain, front view.
PDB entry 5fpg coloured by chain, side view.
PDB entry 5fpg coloured by chain, top view.
Source organism: Homo sapiens
Assembly composition:
monomeric (preferred)
Entry contents: 1 distinct polypeptide molecule

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Assemblies

Assembly 1 (preferred)
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Assembly Name: Poly [ADP-ribose] polymerase tankyrase-2
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Multimeric state: monomeric
Accessible surface area: 10400.86 Å2
Buried surface area: 0.0 Å2
Dissociation area: 0 Å2
Dissociation energy (ΔGdiss): 0 kcal/mol
Dissociation entropy (TΔSdiss): 0 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-190549
Assembly 2
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Assembly Name: Poly [ADP-ribose] polymerase tankyrase-2
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Multimeric state: monomeric
Accessible surface area: 10464.76 Å2
Buried surface area: 0.0 Å2
Dissociation area: 0 Å2
Dissociation energy (ΔGdiss): 0 kcal/mol
Dissociation entropy (TΔSdiss): 0 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-190549

Macromolecules

Poly [ADP-ribose] polymerase tankyrase-2
Chains: A, B
Length: 240 amino acids
Theoretical weight: 27.3 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: Q9H2K2 (Residues: 946-1162; Coverage: 19%)
Gene names: PARP5B, TANK2, TNKL, TNKS2
Pfam: Poly(ADP-ribose) polymerase catalytic domain
InterPro:
CATH: Phosphoenolpyruvate Carboxykinase; domain 3
Poly [ADP-ribose] polymerase tankyrase-2 in PDB entry 5fpg, assembly 1, front view.
Poly [ADP-ribose] polymerase tankyrase-2 in PDB entry 5fpg, assembly 1, side view.
Poly [ADP-ribose] polymerase tankyrase-2 in PDB entry 5fpg, assembly 1, top view.
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