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Crystal structure of the catalytic domain of human JARID1B in complex with pyruvate

X-ray diffraction
2.03Å resolution
PDB entry 5fy9 coloured by chain, front view.
PDB entry 5fy9 coloured by chain, side view.
PDB entry 5fy9 coloured by chain, top view.
Source organism: Homo sapiens
Assembly composition:
monomeric (preferred)
Entry contents: 1 distinct polypeptide molecule

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Assemblies

Assembly 1 (preferred)
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Assembly Name: Lysine-specific demethylase 5B
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Multimeric state: monomeric
Accessible surface area: 20198.68 Å2
Buried surface area: 3147.28 Å2
Dissociation area: 0 Å2
Dissociation energy (ΔGdiss): 0 kcal/mol
Dissociation entropy (TΔSdiss): 0 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-193714

Macromolecules

Lysine-specific demethylase 5B
Chain: A
Length: 479 amino acids
Theoretical weight: 55.21 KDa
Source organism: Homo sapiens
Expression system: Spodoptera frugiperda
UniProt:
  • Canonical: Q9UGL1 (Residues: 26-101, 374-770; Coverage: 31%)
  • Best match: Q9UGL1-2 (Residues: 410-806)
Gene names: JARID1B, KDM5B, PLU1, RBBP2H1
Pfam:
InterPro:
CATH: Cupin
Lysine-specific demethylase 5B in PDB entry 5fy9, assembly 1, front view.
Lysine-specific demethylase 5B in PDB entry 5fy9, assembly 1, side view.
Lysine-specific demethylase 5B in PDB entry 5fy9, assembly 1, top view.
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