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Crystal structure of human MTH1(G2K/D120N mutant) in complex with 8-oxo-dGTP at pH 7.0

X-ray diffraction
1.5Å resolution
PDB entry 5ghm coloured by chain, front view.
PDB entry 5ghm coloured by chain, side view.
PDB entry 5ghm coloured by chain, top view.
Source organism: Homo sapiens
Assembly composition:
monomeric (preferred)
Entry contents: 1 distinct polypeptide molecule

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Assemblies

Assembly 1 (preferred)
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Assembly Name: Oxidized purine nucleoside triphosphate hydrolase
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Multimeric state: monomeric
Accessible surface area: 8279.48 Å2
Buried surface area: 883.45 Å2
Dissociation area: 385.19 Å2
Dissociation energy (ΔGdiss): 4.82 kcal/mol
Dissociation entropy (TΔSdiss): 5.45 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-153202
Assembly 2
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Assembly Name: Oxidized purine nucleoside triphosphate hydrolase
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Multimeric state: monomeric
Accessible surface area: 8317.89 Å2
Buried surface area: 724.55 Å2
Dissociation area: 362.27 Å2
Dissociation energy (ΔGdiss): -1.77 kcal/mol
Dissociation entropy (TΔSdiss): 5.36 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-153202

Macromolecules

Oxidized purine nucleoside triphosphate hydrolase
Chains: A, B
Length: 156 amino acids
Theoretical weight: 18.04 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: P36639 (Residues: 1-156; Coverage: 100%)
Gene names: MTH1, NUDT1
Pfam: NUDIX domain
InterPro:
CATH: Nucleoside Triphosphate Pyrophosphohydrolase
Oxidized purine nucleoside triphosphate hydrolase in PDB entry 5ghm, assembly 1, front view.
Oxidized purine nucleoside triphosphate hydrolase in PDB entry 5ghm, assembly 1, side view.
Oxidized purine nucleoside triphosphate hydrolase in PDB entry 5ghm, assembly 1, top view.
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