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Crystal structure of T brucei phosphodiesterase B2 bound to compound 13e

X-ray diffraction
1.66Å resolution
PDB entry 5h2q coloured by chain, front view.
PDB entry 5h2q coloured by chain, side view.
PDB entry 5h2q coloured by chain, top view.
Source organism: Trypanosoma brucei brucei TREU927
Assembly composition:
monomeric (preferred)
Entry contents: 1 distinct polypeptide molecule

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Assemblies

Assembly 1 (preferred)
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Assembly Name: Phosphodiesterase
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Multimeric state: monomeric
Accessible surface area: 14302.94 Å2
Buried surface area: 236.63 Å2
Dissociation area: 74 Å2
Dissociation energy (ΔGdiss): 15.92 kcal/mol
Dissociation entropy (TΔSdiss): -1.46 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-174418
Assembly 2
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Assembly Name: Phosphodiesterase
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Multimeric state: monomeric
Accessible surface area: 14665.76 Å2
Buried surface area: 237.95 Å2
Dissociation area: 74.62 Å2
Dissociation energy (ΔGdiss): 16.95 kcal/mol
Dissociation entropy (TΔSdiss): -1.46 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-174418

Macromolecules

Phosphodiesterase
Chains: A, B
Length: 337 amino acids
Theoretical weight: 38.5 KDa
Source organism: Trypanosoma brucei brucei TREU927
UniProt:
  • Canonical: Q38F42 (Residues: 586-918; Coverage: 36%)
Gene name: Tb09.160.3630
Pfam: 3'5'-cyclic nucleotide phosphodiesterase
InterPro:
CATH: 3'5'-cyclic nucleotide phosphodiesterase, catalytic domain
Phosphodiesterase in PDB entry 5h2q, assembly 1, front view.
Phosphodiesterase in PDB entry 5h2q, assembly 1, side view.
Phosphodiesterase in PDB entry 5h2q, assembly 1, top view.
PDBe-KB: UniProt Coverage View: Q38F42  
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