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Dissecting Therapeutic Resistance to ERK Inhibition Rat Mutant SCH772984 in complex with (3R)-1-(2-oxo-2-{4-[4-(pyrimidin-2-yl)phenyl]piperazin-1-yl}ethyl)-N-[3-(pyridin-4-yl)-2H-indazol-5-yl]pyrrolidine-3-carboxamide

X-ray diffraction
1.69Å resolution
PDB entry 5hd7 coloured by chain, front view.
PDB entry 5hd7 coloured by chain, side view.
PDB entry 5hd7 coloured by chain, top view.
Source organism: Rattus norvegicus
Assembly composition:
monomeric (preferred)
Entry contents: 1 distinct polypeptide molecule

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Assemblies

Assembly 1 (preferred)
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Assembly Name: Mitogen-activated protein kinase 1
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Multimeric state: monomeric
Accessible surface area: 16551.99 Å2
Buried surface area: 928.56 Å2
Dissociation area: 70.56 Å2
Dissociation energy (ΔGdiss): 8.66 kcal/mol
Dissociation entropy (TΔSdiss): 0.63 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-158941

Macromolecules

Mitogen-activated protein kinase 1
Chain: A
Length: 365 amino acids
Theoretical weight: 42.29 KDa
Source organism: Rattus norvegicus
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: P63086 (Residues: 1-358; Coverage: 100%)
Gene names: Erk2, Mapk, Mapk1, Prkm1
Pfam: Protein kinase domain
InterPro:
CATH:
Mitogen-activated protein kinase 1 in PDB entry 5hd7, assembly 1, front view.
Mitogen-activated protein kinase 1 in PDB entry 5hd7, assembly 1, side view.
Mitogen-activated protein kinase 1 in PDB entry 5hd7, assembly 1, top view.
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