› › Structure analysis

Structure of the T. brucei haptoglobin-haemoglobin receptor bound to human haptolgobin-haemoglobin

X-ray diffraction
2.9Å resolution
PDB entry 5hu6 coloured by chain, front view.
PDB entry 5hu6 coloured by chain, side view.
PDB entry 5hu6 coloured by chain, top view.
Source organisms:
Assembly composition:
hetero tetramer (preferred)
Entry contents: 4 distinct polypeptide molecules

Quick links

Assemblies

Assembly 1 (preferred)
Download    3D Visualisation
Multimeric state: hetero tetramer
Accessible surface area: 33857.79 Å2
Buried surface area: 9782.46 Å2
Dissociation area: 1,289.43 Å2
Dissociation energy (ΔGdiss): 6.46 kcal/mol
Dissociation entropy (TΔSdiss): 13.92 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-133189

Macromolecules

Hemoglobin subunit alpha
Chain: A
Length: 141 amino acids
Theoretical weight: 15.15 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
  • Canonical: P69905 (Residues: 2-142; Coverage: 99%)
Gene names: HBA1, HBA2
Pfam: Globin
InterPro:
CATH: Globins
Hemoglobin subunit alpha in PDB entry 5hu6, assembly 1, front view.
Hemoglobin subunit alpha in PDB entry 5hu6, assembly 1, side view.
Hemoglobin subunit alpha in PDB entry 5hu6, assembly 1, top view.
Molecule details ›

Search similar proteins

Hemoglobin subunit beta
Chain: B
Length: 141 amino acids
Theoretical weight: 15.22 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
  • Canonical: P68871 (Residues: 3-143; Coverage: 96%)
Gene name: HBB
Pfam: Globin
InterPro:
CATH: Globins
Hemoglobin subunit beta in PDB entry 5hu6, assembly 1, front view.
Hemoglobin subunit beta in PDB entry 5hu6, assembly 1, side view.
Hemoglobin subunit beta in PDB entry 5hu6, assembly 1, top view.
Molecule details ›

Search similar proteins

Haptoglobin beta chain
Chain: C
Length: 259 amino acids
Theoretical weight: 28.79 KDa
Source organism: Homo sapiens
Expression system: Spodoptera frugiperda
UniProt:
  • Canonical: P00738 (Residues: 148-406; Coverage: 67%)
Gene name: HP
Pfam: Trypsin
InterPro:
Haptoglobin beta chain in PDB entry 5hu6, assembly 1, front view.
Haptoglobin beta chain in PDB entry 5hu6, assembly 1, side view.
Haptoglobin beta chain in PDB entry 5hu6, assembly 1, top view.
Molecule details ›

Search similar proteins

Haptoglobin-hemoglobin receptor
Chain: D
Length: 260 amino acids
Theoretical weight: 27.93 KDa
Source organism: Trypanosoma brucei brucei
Expression system: Escherichia coli
UniProt:
  • Canonical: Q581F2 (Residues: 38-297; Coverage: 71%)
Gene names: Tb06.28F21.220, Tb927.6.440
Pfam: Haptoglobin-hemoglobin receptor
CATH: Ferritin
Haptoglobin-hemoglobin receptor in PDB entry 5hu6, assembly 1, front view.
Haptoglobin-hemoglobin receptor in PDB entry 5hu6, assembly 1, side view.
Haptoglobin-hemoglobin receptor in PDB entry 5hu6, assembly 1, top view.
Molecule details ›

Search similar proteins

Quick links