› 5i2x

X-ray diffraction
3Å resolution

Crystal Structure of TPP1 K170del

Released:
DOI: 10.2210/pdb5i2x/pdb
PDB entry 5i2x coloured by chain, front view.
PDB entry 5i2x coloured by chain, side view.
PDB entry 5i2x coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Structural and functional consequences of a disease mutation in the telomere protein TPP1.
Bisht K, Smith EM, Tesmer VM, Nandakumar J
Proc Natl Acad Sci U S A 113 13021-13026 (2016)
PMID: 27807141

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-572227 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Adrenocortical dysplasia protein homolog Chains: A, B
Molecule details ›
Chains: A, B
Length: 160 amino acids
Theoretical weight: 17.43 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: Q96AP0 (Residues: 4-164; Coverage: 35%)
Gene names: ACD, PIP1, PTOP, TINT1, TPP1
Sequence domains: Shelterin complex subunit, TPP1/ACD
Structure domains: OB fold (Dihydrolipoamide Acetyltransferase, E2P)

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 21-ID-D
Spacegroup: I4122
Unit cell:
a: 119.026Å b: 119.026Å c: 170.778Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.195 0.192 0.226
Expression system: Escherichia coli BL21(DE3)

Quick links

Citations

7 review citations

Shaping human telomeres: from shelterin and CST complexes to telomeric chromatin organization.
Lim et al. (2021)
6 more

3 mentions without citation

POT1-TPP1 telomere length regulation and disease.
Aramburu et al. (2020)
2 more