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Crystal Structure of TPP1 K170del

X-ray diffraction
3Å resolution
PDB entry 5i2x coloured by chain, front view.
PDB entry 5i2x coloured by chain, side view.
PDB entry 5i2x coloured by chain, top view.
Source organism: Homo sapiens
Assembly composition:
monomeric (preferred)
Entry contents: 1 distinct polypeptide molecule

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Assemblies

Assembly 1 (preferred)
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Assembly Name: Adrenocortical dysplasia protein homolog
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Multimeric state: monomeric
Accessible surface area: 9786.16 Å2
Buried surface area: 0.0 Å2
Dissociation area: 0 Å2
Dissociation energy (ΔGdiss): 0 kcal/mol
Dissociation entropy (TΔSdiss): 0 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-188358
Assembly 2
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Assembly Name: Adrenocortical dysplasia protein homolog
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Multimeric state: monomeric
Accessible surface area: 8084.04 Å2
Buried surface area: 0.0 Å2
Dissociation area: 0 Å2
Dissociation energy (ΔGdiss): 0 kcal/mol
Dissociation entropy (TΔSdiss): 0 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-188358

Macromolecules

Adrenocortical dysplasia protein homolog
Chains: A, B
Length: 160 amino acids
Theoretical weight: 17.43 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: Q96AP0 (Residues: 4-164; Coverage: 35%)
Gene names: ACD, PIP1, PTOP, TINT1, TPP1
Pfam: Shelterin complex subunit, TPP1/ACD
InterPro:
CATH: OB fold (Dihydrolipoamide Acetyltransferase, E2P)
Adrenocortical dysplasia protein homolog in PDB entry 5i2x, assembly 1, front view.
Adrenocortical dysplasia protein homolog in PDB entry 5i2x, assembly 1, side view.
Adrenocortical dysplasia protein homolog in PDB entry 5i2x, assembly 1, top view.
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