› › Structure analysis

CDK8-CYCC IN COMPLEX WITH [(S)-2-(4-Chloro-phenyl)-pyrrolidin-1-yl]-(5-methyl-imidazo[5,1-b][1,3,4]thiadiazol-2-yl)-methanone

X-ray diffraction
2.18Å resolution
PDB entry 5icp coloured by chain, front view.
PDB entry 5icp coloured by chain, side view.
PDB entry 5icp coloured by chain, top view.
Source organism: Homo sapiens
Assembly composition:
hetero dimer (preferred)
Entry contents: 2 distinct polypeptide molecules

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Assemblies

Assembly 1 (preferred)
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Assembly Name: Cyclin C-CDK8 complex
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Multimeric state: hetero dimer
Accessible surface area: 28551.3 Å2
Buried surface area: 5955.79 Å2
Dissociation area: 1,834.2 Å2
Dissociation energy (ΔGdiss): 24.4 kcal/mol
Dissociation entropy (TΔSdiss): 13.48 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-150300
Complex Portal ID: CPX-1969

Macromolecules

Cyclin-dependent kinase 8
Chain: A
Length: 364 amino acids
Theoretical weight: 42.55 KDa
Source organism: Homo sapiens
Expression system: Spodoptera frugiperda
UniProt:
  • Canonical: P49336 (Residues: 1-362; Coverage: 78%)
Gene name: CDK8
Pfam: Protein kinase domain
InterPro:
CATH:
Cyclin-dependent kinase 8 in PDB entry 5icp, assembly 1, front view.
Cyclin-dependent kinase 8 in PDB entry 5icp, assembly 1, side view.
Cyclin-dependent kinase 8 in PDB entry 5icp, assembly 1, top view.
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Cyclin-C
Chain: B
Length: 267 amino acids
Theoretical weight: 31.66 KDa
Source organism: Homo sapiens
Expression system: Spodoptera frugiperda
UniProt:
  • Canonical: P24863 (Residues: 1-264; Coverage: 93%)
Gene name: CCNC
Pfam:
InterPro:
CATH: Cyclin-like
Cyclin-C in PDB entry 5icp, assembly 1, front view.
Cyclin-C in PDB entry 5icp, assembly 1, side view.
Cyclin-C in PDB entry 5icp, assembly 1, top view.
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