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Aminoglycoside Phosphotransferase (2'')-Ia (CTD of AAC(6')-Ie/APH(2'')-Ia) in complex with GMPPNP and Magnesium

Source organism: Staphylococcus aureus
Biochemical function: not assigned
Biological process: not assigned
Cellular component: not assigned

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EC 2.7.1.190: Aminoglycoside 2''-phosphotransferase

Reaction catalysed:
GTP + gentamicin = GDP + gentamicin 2''-phosphate
Systematic name:
GTP:gentamicin 2''-O-phosphotransferase
Alternative Name(s):
  • APH(2'')
  • Aminoglycoside (2'') kinase
  • AphD (gene name)
  • Gentamicin kinase
  • Gentamicin phosphotransferase

GO terms

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned

Sequence family

Pfam Protein family (Pfam)
PF01636
Domain description: Phosphotransferase enzyme family
Occurring in:
  1. Bifunctional AAC/APH
The deposited structure of PDB entry 5iqa contains 4 copies of Pfam domain PF01636 (Phosphotransferase enzyme family) in Bifunctional AAC/APH. Showing 1 copy in chain B.

InterPro InterPro annotations
IPR002575
Domain description: Aminoglycoside phosphotransferase
Occurring in:
  1. Bifunctional AAC/APH
IPR011009
Domain description: Protein kinase-like domain superfamily
Occurring in:
  1. Bifunctional AAC/APH

Structure domains

CATH CATH domains
3.90.1200.10
Class: Alpha Beta
Architecture: Alpha-Beta Complex
Topology: Aminoglycoside 3'-phosphotransferase; Chain: A, domain 2
Homology: Aminoglycoside 3'-phosphotransferase; Chain: A, domain 2
Occurring in:
  1. Bifunctional AAC/APH
The deposited structure of PDB entry 5iqa contains 4 copies of CATH domain 3.90.1200.10 (Aminoglycoside 3'-phosphotransferase; Chain: A, domain 2) in Bifunctional AAC/APH. Showing 1 copy in chain B.
3.30.200.20
Class: Alpha Beta
Architecture: 2-Layer Sandwich
Topology: Phosphorylase Kinase; domain 1
Homology: Phosphorylase Kinase; domain 1
Occurring in:
  1. Bifunctional AAC/APH
The deposited structure of PDB entry 5iqa contains 4 copies of CATH domain 3.30.200.20 (Phosphorylase Kinase; domain 1) in Bifunctional AAC/APH. Showing 1 copy in chain B.

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