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Structure of human Melanoma Inhibitory Activity (MIA) Protein in complex with Pyrimidin-2-amine

X-ray diffraction
1.39Å resolution
PDB entry 5ixb coloured by chain, front view.
PDB entry 5ixb coloured by chain, side view.
PDB entry 5ixb coloured by chain, top view.
Source organism: Homo sapiens
Assembly composition:
monomeric (preferred)
Entry contents: 1 distinct polypeptide molecule

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Assemblies

Assembly 1 (preferred)
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Assembly Name: Melanoma-derived growth regulatory protein
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Multimeric state: monomeric
Accessible surface area: 6422.0 Å2
Buried surface area: 229.09 Å2
Dissociation area: 114.54 Å2
Dissociation energy (ΔGdiss): 0.77 kcal/mol
Dissociation entropy (TΔSdiss): -0.18 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-172553
Assembly 2
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Assembly Name: Melanoma-derived growth regulatory protein
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Multimeric state: monomeric
Accessible surface area: 6423.83 Å2
Buried surface area: 226.5 Å2
Dissociation area: 113.25 Å2
Dissociation energy (ΔGdiss): 1.14 kcal/mol
Dissociation entropy (TΔSdiss): -0.18 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-172553

Macromolecules

Melanoma-derived growth regulatory protein
Chains: A, B
Length: 108 amino acids
Theoretical weight: 12.26 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: Q16674 (Residues: 25-131; Coverage: 100%)
Gene name: MIA
Pfam: Variant SH3 domain
InterPro:
CATH: SH3 Domains
Melanoma-derived growth regulatory protein in PDB entry 5ixb, assembly 1, front view.
Melanoma-derived growth regulatory protein in PDB entry 5ixb, assembly 1, side view.
Melanoma-derived growth regulatory protein in PDB entry 5ixb, assembly 1, top view.
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