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T. congolense haptoglobin-haemoglobin receptor in complex with haemoglobin

X-ray diffraction
3.2Å resolution
PDB entry 5jdo coloured by chain, front view.
PDB entry 5jdo coloured by chain, side view.
PDB entry 5jdo coloured by chain, top view.
Source organisms:
Assembly composition:
hetero hexamer (preferred)
Entry contents: 6 distinct polypeptide molecules

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Assemblies

Assembly 1 (preferred)
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Multimeric state: hetero hexamer
Accessible surface area: 46735.54 Å2
Buried surface area: 16599.68 Å2
Dissociation area: 2,094.62 Å2
Dissociation energy (ΔGdiss): 8.47 kcal/mol
Dissociation entropy (TΔSdiss): 15.39 kcal/mol
Symmetry number: 2
PDBe Complex ID: PDB-CPX-124131

Macromolecules

Haptoglobin-haemoglobin receptor
Chain: A
Length: 249 amino acids
Theoretical weight: 26.56 KDa
Source organism: Trypanosoma congolense
Expression system: Escherichia coli
UniProt:
  • Canonical: G0UVW6 (Residues: 116-364; Coverage: 64%)
Gene name: TCIL3000_10_2930
Pfam: Haptoglobin-hemoglobin receptor
CATH: Ferritin
Haptoglobin-haemoglobin receptor in PDB entry 5jdo, assembly 1, front view.
Haptoglobin-haemoglobin receptor in PDB entry 5jdo, assembly 1, side view.
Haptoglobin-haemoglobin receptor in PDB entry 5jdo, assembly 1, top view.
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Haptoglobin-haemoglobin receptor
Chain: B
Length: 245 amino acids
Theoretical weight: 26.12 KDa
Source organism: Trypanosoma congolense
Expression system: Escherichia coli
UniProt:
  • Canonical: G0UVW6 (Residues: 116-360; Coverage: 63%)
Gene name: TCIL3000_10_2930
Pfam: Haptoglobin-hemoglobin receptor
CATH: Ferritin
Haptoglobin-haemoglobin receptor in PDB entry 5jdo, assembly 1, front view.
Haptoglobin-haemoglobin receptor in PDB entry 5jdo, assembly 1, side view.
Haptoglobin-haemoglobin receptor in PDB entry 5jdo, assembly 1, top view.
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Hemoglobin subunit alpha
Chain: C
Length: 141 amino acids
Theoretical weight: 15.15 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
  • Canonical: P69905 (Residues: 2-142; Coverage: 99%)
Gene names: HBA1, HBA2
Pfam: Globin
InterPro:
CATH: Globins
Hemoglobin subunit alpha in PDB entry 5jdo, assembly 1, front view.
Hemoglobin subunit alpha in PDB entry 5jdo, assembly 1, side view.
Hemoglobin subunit alpha in PDB entry 5jdo, assembly 1, top view.
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Hemoglobin subunit beta
Chain: D
Length: 145 amino acids
Theoretical weight: 15.79 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
  • Canonical: P68871 (Residues: 3-147; Coverage: 99%)
Gene name: HBB
Pfam: Globin
InterPro:
CATH: Globins
Hemoglobin subunit beta in PDB entry 5jdo, assembly 1, front view.
Hemoglobin subunit beta in PDB entry 5jdo, assembly 1, side view.
Hemoglobin subunit beta in PDB entry 5jdo, assembly 1, top view.
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Hemoglobin subunit alpha
Chain: E
Length: 140 amino acids
Theoretical weight: 14.99 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
  • Canonical: P69905 (Residues: 2-141; Coverage: 99%)
Gene names: HBA1, HBA2
Pfam: Globin
InterPro:
CATH: Globins
Hemoglobin subunit alpha in PDB entry 5jdo, assembly 1, front view.
Hemoglobin subunit alpha in PDB entry 5jdo, assembly 1, side view.
Hemoglobin subunit alpha in PDB entry 5jdo, assembly 1, top view.
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Hemoglobin subunit beta
Chain: F
Length: 144 amino acids
Theoretical weight: 15.65 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
  • Canonical: P68871 (Residues: 3-146; Coverage: 98%)
Gene name: HBB
Pfam: Globin
InterPro:
CATH: Globins
Hemoglobin subunit beta in PDB entry 5jdo, assembly 1, front view.
Hemoglobin subunit beta in PDB entry 5jdo, assembly 1, side view.
Hemoglobin subunit beta in PDB entry 5jdo, assembly 1, top view.
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