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Complex of IRF-3 with CBP

X-ray diffraction
2.5Å resolution
PDB entry 5jem coloured by chain, front view.
PDB entry 5jem coloured by chain, side view.
PDB entry 5jem coloured by chain, top view.
Source organism: Homo sapiens
Assembly composition:
hetero tetramer (preferred)
Entry contents: 2 distinct polypeptide molecules

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Assemblies

Assembly 1 (preferred)
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Assembly Name: Interferon regulatory factor 3 and CREB-binding protein
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Multimeric state: hetero tetramer
Accessible surface area: 21691.77 Å2
Buried surface area: 7750.66 Å2
Dissociation area: 2,018.63 Å2
Dissociation energy (ΔGdiss): 14.77 kcal/mol
Dissociation entropy (TΔSdiss): 13.5 kcal/mol
Symmetry number: 2
PDBe Complex ID: PDB-CPX-172057
Assembly 2
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Assembly Name: Interferon regulatory factor 3 and CREB-binding protein
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Multimeric state: hetero tetramer
Accessible surface area: 21457.33 Å2
Buried surface area: 7880.08 Å2
Dissociation area: 2,115.79 Å2
Dissociation energy (ΔGdiss): 14.35 kcal/mol
Dissociation entropy (TΔSdiss): 13.52 kcal/mol
Symmetry number: 2
PDBe Complex ID: PDB-CPX-172057

Macromolecules

Interferon regulatory factor 3
Chains: A, B, E, G
Length: 213 amino acids
Theoretical weight: 23.77 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: Q14653 (Residues: 189-398; Coverage: 49%)
  • Best match: Q14653-4 (Residues: 189-327)
Gene name: IRF3
Pfam: Interferon-regulatory factor 3
InterPro:
CATH: Tumour Suppressor Smad4
Interferon regulatory factor 3 in PDB entry 5jem, assembly 1, front view.
Interferon regulatory factor 3 in PDB entry 5jem, assembly 1, side view.
Interferon regulatory factor 3 in PDB entry 5jem, assembly 1, top view.
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CREB-binding protein
Chains: C, D, F, H
Length: 47 amino acids
Theoretical weight: 5.27 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: Q92793 (Residues: 2065-2111; Coverage: 2%)
Gene names: CBP, CREBBP
Pfam: Creb binding
InterPro:
CATH: Nuclear receptor coactivator, CREB-bp-like, interlocking domain
CREB-binding protein in PDB entry 5jem, assembly 1, front view.
CREB-binding protein in PDB entry 5jem, assembly 1, side view.
CREB-binding protein in PDB entry 5jem, assembly 1, top view.
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