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Crystal structure of the HAT domain of sart3 in complex with USP15 DUSP-UBL domain

X-ray diffraction
3.01Å resolution
PDB entry 5jjw coloured by chain, front view.
PDB entry 5jjw coloured by chain, side view.
PDB entry 5jjw coloured by chain, top view.
Source organism: Homo sapiens
Assembly composition:
hetero dimer (preferred)
Entry contents: 2 distinct polypeptide molecules

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Assemblies

Assembly 1 (preferred)
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Assembly Name: Ubiquitin carboxyl-terminal hydrolase 15 and Squamous cell carcinoma antigen recognized by T-cells 3
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Multimeric state: hetero dimer
Accessible surface area: 23971.09 Å2
Buried surface area: 1413.39 Å2
Dissociation area: 580.08 Å2
Dissociation energy (ΔGdiss): -2.9 kcal/mol
Dissociation entropy (TΔSdiss): 12.3 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-172161

Macromolecules

Squamous cell carcinoma antigen recognized by T-cells 3
Chain: A
Length: 300 amino acids
Theoretical weight: 35.93 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: Q15020 (Residues: 280-578; Coverage: 31%)
Gene names: KIAA0156, SART3, TIP110
InterPro:
Squamous cell carcinoma antigen recognized by T-cells 3 in PDB entry 5jjw, assembly 1, front view.
Squamous cell carcinoma antigen recognized by T-cells 3 in PDB entry 5jjw, assembly 1, side view.
Squamous cell carcinoma antigen recognized by T-cells 3 in PDB entry 5jjw, assembly 1, top view.
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Ubiquitin carboxyl-terminal hydrolase 15
Chain: B
Length: 224 amino acids
Theoretical weight: 26.17 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: Q9Y4E8 (Residues: 1-223; Coverage: 23%)
Gene names: KIAA0529, USP15
Pfam:
InterPro:
Ubiquitin carboxyl-terminal hydrolase 15 in PDB entry 5jjw, assembly 1, front view.
Ubiquitin carboxyl-terminal hydrolase 15 in PDB entry 5jjw, assembly 1, side view.
Ubiquitin carboxyl-terminal hydrolase 15 in PDB entry 5jjw, assembly 1, top view.
Molecule details ›

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